Evidence map›Paper›PMID 36972684›Full record

ArticleNature2023

Formin-mediated nuclear actin at androgen receptors promotes transcription.

Julian Knerr, Ralf Werner, Carsten Schwan, Hong Wang, Peter Gebhardt, Helga Grötsch, Almuth Caliebe, Malte Spielmann, Paul-Martin Holterhus, Robert Grosse and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Turkish journal of medical sciences · 2026
    Article
  9. Recent advances in nuclear actin research.Nucleus (Austin, Tex.) · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Differences of sex development.Nature reviews. Disease primers · 2025
    Review
  14. Article
  15. Article
  16. Review
  17. Transcription regulation by biomolecular condensates.Nature reviews. Molecular cell biology · 2025
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Julian KnerrInstitute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-2614-6185
Ralf WernerDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Endocrinology and Diabetes, University of Lübeck, Lübeck, Germany.ORCID 0000-0003-3718-3595
Carsten SchwanInstitute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty, University of Freiburg, Freiburg, Germany.
Hong WangInstitute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-3120-1679
Peter GebhardtInstitute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty, University of Freiburg, Freiburg, Germany.
Helga GrötschDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Endocrinology and Diabetes, University of Lübeck, Lübeck, Germany.ORCID 0000-0003-1948-3922
Almuth CaliebeInstitute of Human Genetics, University Hospital Schleswig-Holstein, University of Lübeck and Kiel University, Lübeck, Kiel, Germany.ORCID 0000-0003-2157-425X
Malte SpielmannInstitute of Human Genetics, University Hospital Schleswig-Holstein, University of Lübeck and Kiel University, Lübeck, Kiel, Germany.ORCID 0000-0002-0583-4683
Paul-Martin HolterhusDepartment of Paediatrics, Division of Paediatric Endocrinology and Diabetes, University Hospital of Schleswig-Holstein, Kiel, Germany.ORCID 0000-0002-9308-3129
Robert GrosseInstitute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty, University of Freiburg, Freiburg, Germany. robert.grosse@pharmakol.uni-freiburg.de.ORCID 0000-0002-3380-5273
Nadine C HornigInstitute of Human Genetics, University Hospital Schleswig-Holstein, University of Lübeck and Kiel University, Lübeck, Kiel, Germany. nhornig@medgen.uni-kiel.de.ORCID 0000-0003-2469-752X
University of Freiburg · DEChristian-Albrechts-Universität zu Kiel · DEGalaxy Biotech (United States) · USUniversity Hospital Schleswig-Holstein · DEUniversity of Lübeck · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Steroid hormone receptors are ligand-binding transcription factors essential for mammalian physiology. The androgen receptor (AR) binds androgens mediating gene expression for sexual, somatic and behavioural functions, and is involved in various conditions including androgen insensitivity syndrome and prostate cancer

Indexed as

ActinsForminsNuclear ProteinsReceptors, AndrogenTranscription, GeneticAndrogen-Insensitivity SyndromeAndrogensGene Expression RegulationHumansMicrofilament ProteinsPolymerizationProstate-Specific AntigenProstatic Neoplasmsrho GTP-Binding ProteinsRNA Polymerase IISignal TransductionActinsAndrogensAR protein, humanDAAM2 protein, humanForminsMicrofilament ProteinsNuclear ProteinsProstate-Specific AntigenReceptors, Androgenrho GTP-Binding ProteinsRNA Polymerase IISteroidsTestosterone

Identifiers

PMID36972684
OpenAlexW4360999508

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.