Evidence map›Paper›PMID 36972611›Full record

ReviewAnnual review of neuroscience2023

The Computational and Neural Bases of Context-Dependent Learning.

James B Heald, Daniel M Wolpert, Máté Lengyel

Abstract readReview
In one paragraph

Review in Annual review of neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Categorization is 'baked' into the brain.Nature reviews. Neuroscience · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Neural mechanisms of flexible perceptual inference.PLoS computational biology · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

James B HealdDepartment of Neuroscience and Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA; email: jamesbheald@gmail.com, wolpert@columbia.edu.
Daniel M WolpertDepartment of Neuroscience and Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA; email: jamesbheald@gmail.com, wolpert@columbia.edu.
Máté LengyelComputational and Biological Learning Lab, Department of Engineering, University of Cambridge, Cambridge, United Kingdom; email: m.lengyel@eng.cam.ac.uk.

Funding

Modeling multi-area dynamics during motor controlU19NS104649 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JESSELL, THOMAS M. · 2017 to 2021
$15.3M
Computations in Human Motor LearningR01NS117699 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WOLPERT, DANIEL · 2021 to 2025
$2.5M
NINDS NIH HHS R01 NS117699NINDS NIH HHS U19 NS104649Wellcome TrustWellcome Trust 212262/Z/18/Z
6 · The paper itself

Abstract

Flexible behavior requires the creation, updating, and expression of memories to depend on context. While the neural underpinnings of each of these processes have been intensively studied, recent advances in computational modeling revealed a key challenge in context-dependent learning that had been largely ignored previously: Under naturalistic conditions, context is typically uncertain, necessitating contextual inference. We review a theoretical approach to formalizing context-dependent learning in the face of contextual uncertainty and the core computations it requires. We show how this approach begins to organize a large body of disparate experimental observations, from multiple levels of brain organization (including circuits, systems, and behavior) and multiple brain regions (most prominently the prefrontal cortex, the hippocampus, and motor cortices), into a coherent framework. We argue that contextual inference may also be key to understanding continual learning in the brain. This theory-driven perspective places contextual inference as a core component of learning.

Indexed as

BrainLearningComputer SimulationHippocampusPrefrontal CortexBayesian inferencecontext-dependent learningcontinual learninghippocampuslearningmemorymotor cortexneural computationprefrontal cortexthalamus

Identifiers

PMID36972611
PMCPMC10348919

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.