Evidence map›Paper›PMID 36972543›Full record

ArticleAnnals of internal medicine2023

Cases in Precision Medicine: Is There an Obligation to Return Reinterpreted Genetic Results to Former Patients?

Paul S Appelbaum, Wylie Burke, Erik Parens, Jessica Roberts, Sara M Berger, Wendy K Chung

Abstract read
In one paragraph

Article in Annals of internal medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paul S AppelbaumDepartment of Psychiatry, Columbia University Irving Medical Center and New York State Psychiatric Institute, New York, New York (P.S.A.).ORCID 0000-0002-1940-0042
Wylie BurkeDepartment of Bioethics and Humanities, University of Washington, Seattle, Washington (W.B.).ORCID 0000-0003-2914-0560
Erik ParensThe Hastings Center, Garrison, New York (E.P.).
Jessica RobertsHealth Law & Policy Institute, University of Houston Law Center, Houston, Texas (J.R.).ORCID 0000-0002-9355-0380
Sara M BergerDepartment of Pediatrics, Columbia University Irving Medical Center, New York, New York (S.M.B.).ORCID 0000-0003-0525-1346
Wendy K ChungDepartments of Pediatrics and Medicine, Columbia University Irving Medical Center, New York, New York (W.K.C.).ORCID 0000-0003-3438-5685

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Center for Research on Ethical, Legal & Social Implications of Psychiatric, Neurologic & Behavioral GeneticsRM1HG007257 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI APPELBAUM, PAUL STUART · 2018 to 2021
$4.4M
Development of recommendations and policies for genetic variant reclassificationR01HG010365 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI APPELBAUM, PAUL STUART, CHUNG, WENDY K · 2018 to 2021
$2.9M
NCATS NIH HHS UL1 TR001873NHGRI NIH HHS R01 HG010365NHGRI NIH HHS RM1 HG007257
6 · The paper itself

Abstract

Interpretation of many genetic test results can change over time as new data accumulate. Hence, physicians who order genetic tests may subsequently receive revised reports with important implications for patients' medical treatment-even for patients who are no longer in their care. Several of the ethical principles underlying medical practice suggest an obligation to reach out to former patients with this information. Discharging that obligation can be accomplished, at a minimum, by attempting to contact the former patient with their last known contact information.

Indexed as

PhysiciansPrecision MedicineHumans

Identifiers

PMID36972543
PMCPMC10413009

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.