Evidence map›Paper›PMID 36972453›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Treg cells require Izumo1R to regulate γδT cell-driven inflammation in the skin.

Payam Zarin, Yulia Shwartz, Adriana Ortiz-Lopez, Bola S Hanna, Martina Sassone-Corsi, Ya-Chieh Hsu, Diane Mathis, Christophe Benoist

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Extraction and Quantification of Skin Immune Cells and Skin Lipids.Methods in molecular biology (Clifton, N.J.) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Payam ZarinDepartment of Immunology, Harvard Medical School, Boston, MA 02115.
Yulia ShwartzDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138.
Adriana Ortiz-LopezDepartment of Immunology, Harvard Medical School, Boston, MA 02115.
Bola S HannaDepartment of Immunology, Harvard Medical School, Boston, MA 02115.
Martina Sassone-CorsiDepartment of Immunology, Harvard Medical School, Boston, MA 02115.
Ya-Chieh HsuDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138.
Diane MathisDepartment of Immunology, Harvard Medical School, Boston, MA 02115.
Christophe BenoistDepartment of Immunology, Harvard Medical School, Boston, MA 02115.
Harvard University · US

Funding

Treg cell diversity and homeostatic controlR01AI150686 · NIAID · HARVARD MEDICAL SCHOOL · PI BENOIST, CHRISTOPHE O. · 2020 to 2024
$2.6M
T regulatory cell subsets at the microbial interface: determinism and functionR01AI125603 · NIAID · HARVARD MEDICAL SCHOOL · PI BENOIST, CHRISTOPHE O. · 2017 to 2021
$2.1M
NIAID NIH HHS R01 AI125603NIAID NIH HHS R01 AI150686
6 · The paper itself

Abstract

Izumo1R is a pseudo-folate receptor with an essential role in mediating tight oocyte/spermatozoa contacts during fertilization. Intriguingly, it is also expressed in CD4

Indexed as

DermatitisPsoriasisReceptors, Cell SurfaceSkin DiseasesT-Lymphocytes, RegulatoryAnimalsImiquimodInflammationMiceSkinImiquimodReceptors, Cell SurfaceFoxp3psoriasisT regulatory cells

Identifiers

PMID36972453
PMCPMC10083566
OpenAlexW4360992869

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.