Evidence map›Paper›PMID 36972444›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Immunoglobulin G subclasses confer protection against

Xinhai Chen, Haley Gula, Tonu Pius, Chong Ou, Margaryta Gomozkova, Lai-Xi Wang, Olaf Schneewind, Dominique Missiakas

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Conserved moonlighting protein pyruvate dehydrogenase induces robust protection againstProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Xinhai ChenDepartment of Microbiology, Howard Taylor Ricketts Laboratory, The University of Chicago, Lemont, IL 60439.ORCID 0000-0002-6771-6316
Haley GulaDepartment of Microbiology, Howard Taylor Ricketts Laboratory, The University of Chicago, Lemont, IL 60439.ORCID 0000-0002-8475-7435
Tonu PiusDepartment of Microbiology, Howard Taylor Ricketts Laboratory, The University of Chicago, Lemont, IL 60439.ORCID 0000-0002-6348-7456
Chong OuDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742.ORCID 0000-0001-7926-1059
Margaryta GomozkovaDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742.
Lai-Xi WangDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742.ORCID 0000-0003-4293-5819
Olaf SchneewindDepartment of Microbiology, Howard Taylor Ricketts Laboratory, The University of Chicago, Lemont, IL 60439.
Dominique MissiakasDepartment of Microbiology, Howard Taylor Ricketts Laboratory, The University of Chicago, Lemont, IL 60439.ORCID 0000-0001-6482-9633
University of Chicago · USUniversity of Maryland, College Park · US

Funding

Engineering monoclonal antibodies against Staphylococcus aureusR01AI148543 · NIAID · UNIVERSITY OF CHICAGO · PI Dominique Missiakas · 2020 to 2026
$5.5M
Glycoengineering of antibodies to modulate immune functionsR01AI155716 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI LAI-XI WANG · 2020 to 2026
$3.6M
NIAID NIH HHS R01 AI148543NIAID NIH HHS R01 AI155716
6 · The paper itself

Abstract

Antibodies bind target molecules with exquisite specificity. The removal of these targets is mediated by the effector functions of antibodies. We reported earlier that the monoclonal antibody (mAb) 3F6 promotes opsonophagocytic killing of

Indexed as

Immunoglobulin GStaphylococcus aureusAnimalsAntibodies, MonoclonalComplement System ProteinsHumansMammalsMiceMice, Inbred C57BLReceptors, IgGAntibodies, MonoclonalComplement System ProteinsImmunoglobulin GReceptors, IgGantibodyeffector functionneutrophilopsonophagocytosisStaphylococcus aureus

Identifiers

PMID36972444
PMCPMC10083571
OpenAlexW4360992859

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.