Evidence map›Paper›PMID 36972223›Full record

ArticleBiochemistry2023

Histone Deacetylase 1 Inhibition by Peptides Containing a DNA Damage-Induced, Nonenzymatic, Histone Covalent Modification.

Marco Paolo Jacinto, Marc M Greenberg

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Marco Paolo JacintoDepartment of Chemistry, Johns Hopkins University, 3400 N. Charles St., Baltimore, Maryland 21218, United States.
Marc M GreenbergDepartment of Chemistry, Johns Hopkins University, 3400 N. Charles St., Baltimore, Maryland 21218, United States.ORCID 0000-0002-5786-6118
Johns Hopkins University · US

Funding

How Damaged DNA Forms, and its Subsequent Chemistry: Fundamental Studies and ApplicationsR35GM131736 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI MARC M GREENBERG · 2019 to 2026
$4.3M
NIGMS NIH HHS R35 GM131736
6 · The paper itself

Abstract

Treatment of HeLa cells with the DNA damaging agent, bleomycin (BLM), results in the formation of a nonenzymatic 5-methylene-2-pyrrolone histone covalent modification on lysine residues (K

Indexed as

DNA DamageHistone Deacetylase 1HistonesAcetylationDNAHeLa CellsHistone Deacetylase 2HumansPeptidesProtein Processing, Post-TranslationalDNAHistone Deacetylase 1Histone Deacetylase 2HistonesPeptides

Identifiers

PMID36972223
PMCPMC10124317
OpenAlexW4361017524

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.