ArticleeLife2023
Extra-hippocampal contributions to pattern separation.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Temporal Interference Modulates Medial Temporal and Frontoparietal Activity During Mnemonic Discrimination: A High-Resolution Whole-Brain fMRI Investigation.Hippocampus · 2026Article
- Hippocampal mechanisms underlying the resolution of competition in memory and perception.Nature communications · 2026Article
- Computational mechanisms transforming visual codes into sparse representations.Neuroscience and biobehavioral reviews · 2026Review
- The prefrontal cortex across scales: laminar architecture, white-matter constraints, and distributed control in cognition.Brain structure & function · 2026Review
- Encoding-related fMRI BOLD activity predicts subsequent memory for studied scenes, but not subsequent identification of perceptually similar lures.bioRxiv : the preprint server for biology · 2026Article
- Enhanced Contour-Deviant Mismatch Negativity and Mnemonic Representations in Older Musicians.The European journal of neuroscience · 2026Article
- Reactivation during sleep segregates the neural representations of episodic memories.bioRxiv : the preprint server for biology · 2026Article
- Hippocampal patterns and associative memory: Distinct intracranial EEG temporal encoding patterns support memory.bioRxiv : the preprint server for biology · 2026Article
- Hippocampal-prefrontal connectivity relates to inter-individual differences and training gains in distinguishing similar memories.Communications biology · 2025Article
- Dynamically shifting from compositional to conjunctive brain representations supports cognitive task learning.Nature communications · 2025Article
- A compressed code for memory discrimination.bioRxiv : the preprint server for biology · 2025Article
- Memory updating and the structure of event representations.Trends in cognitive sciences · 2025Review
- Schemas, reinforcement learning and the medial prefrontal cortex.Nature reviews. Neuroscience · 2025Review
- Impaired Hippocampal Circuitry and Memory Dysfunction in Schizophrenia.Nature. Mental health · 2025Article
- Contextual Influence on Pattern Separation During Encoding.NeuroSci · 2025Article
- Event Segmentation Promotes the Reorganization of Emotional Memory.Journal of cognitive neuroscience · 2025Article
- Aging and episodic memory specificity: Evidence challenging a domain-general pattern separation decline.PloS one · 2025Article
- Menstrual cycle and perceived stress predict performance on the mnemonic similarity task.PloS one · 2025Article
- Pattern separation involves regions beyond the hippocampus in non-demented elderly individuals: A 7T object lure task fMRI study.Imaging neuroscience (Cambridge, Mass.) · 2024Article
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2 authors.
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Abstract
Pattern separation, or the process by which highly similar stimuli or experiences in memory are represented by non-overlapping neural ensembles, has typically been ascribed to processes supported by the hippocampus. Converging evidence from a wide range of studies, however, suggests that pattern separation is a multistage process supported by a network of brain regions. Based on this evidence, considered together with related findings from the interference resolution literature, we propose the 'cortico-hippocampal pattern separation' (CHiPS) framework, which asserts that brain regions involved in cognitive control play a significant role in pattern separation. Particularly, these regions may contribute to pattern separation by (1) resolving interference in sensory regions that project to the hippocampus, thus regulating its cortical input, or (2) directly modulating hippocampal processes in accordance with task demands. Considering recent interest in how hippocampal operations are modulated by goal states likely represented and regulated by extra-hippocampal regions, we argue that pattern separation is similarly supported by neocortical-hippocampal interactions.
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