ArticleJournal of studies on alcohol and drugs2023
The Interrelationship of the Genetic Risks for Different Forms of Substance Use Disorder in a Swedish National Sample: A Top-Down Genetic Analysis.
Article in Journal of studies on alcohol and drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveThe purpose of this study was to determine, using a top-down genetic analysis, the degree of specificity of the genetic risk factors for individual forms of substance use disorders (SUD).
methodWe examined and followed to December 31, 2018, all individuals born in Sweden between 1960 and 1990 (
resultsAll SUDs were concentrated in those at high versus median risk for all six groups. DUD, CUD, and CSUD showed modest genetic specificity in that they were more concentrated in samples with high genetic liability to each of them than were other SUDs. The differences, however, were modest. No evidence for genetic specificity was seen for AUD, OUD, and SeUD, as other disorders were equally or more concentrated in those at high versus median genetic risk for that form of SUD.
conclusionsIndividuals at high genetic risk for particular forms of SUD typically had elevated rates for all forms of SUDs, consistent with the nonspecificity of much of SUD genetic liability. Evidence of specificity of genetic risk for particular forms of SUD was noted but was quantitatively modest.
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