Evidence map›Paper›PMID 36971731›Full record

ArticleJournal of studies on alcohol and drugs2023

Genetic and Cultural Transmission of Alcohol Use Disorder in Swedish Twin Pedigrees.

Hermine H Maes, Michael C Neale, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist, Kenneth S Kendler

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of studies on alcohol and drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Hermine H MaesDepartment of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia.
Michael C NealeDepartment of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia.
Henrik OhlssonCenter for Primary Health Care Research, Lund University, Malmö, Sweden.
Jan SundquistCenter for Primary Health Care Research, Lund University, Malmö, Sweden.
Kristina SundquistCenter for Primary Health Care Research, Lund University, Malmö, Sweden.
Kenneth S KendlerDepartment of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia.
Lund University · SEVirginia Commonwealth University · US

Funding

Social, Developmental and Genetic Epidemiology of Alcohol Use DisordersR01AA023534 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI KENDLER, KENNETH SEEDMAN, SUNDQUIST, KRISTINA · 2015 to 2023
$4.0M
Psychometric and Genetic Assessments of Substance UseR37DA018673 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI NEALE, MICHAEL CHURTON · 2005 to 2014
$3.7M
Psychometric and Genetic Assessments of Substance UseR01DA018673 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI NEALE, MICHAEL CHURTON · 2004 to 2019
$2.3M
Open Mx: Multipurpose Software for Statistical ModelingR21DA024304 · NIDA · UNIVERSITY OF VIRGINIA · PI BOKER, STEVEN M · 2007 to 2010
$1.1M
NIAAA NIH HHS R01 AA023534NIDA NIH HHS R01 DA018673NIDA NIH HHS R21 DA024304NIDA NIH HHS R37 DA018673
6 · The paper itself

Abstract

objectiveUsing Swedish nationwide registry data, we investigated the contribution of genetic and environmental risk factors to the etiology of alcohol use disorder (AUD) by extended twin pedigree modeling.

methodAUD was defined using public inpatient, outpatient, prescription, and criminal records. Three-generational pedigrees were selected for index individuals born between 1980 and 1990, obtained from the national twin and genealogical registers, whose parents were twins. Relatives of the twins included in the pedigrees were their parents, siblings, spouses, and children. Genetic structural equation modeling was applied to the population-based data on AUD, using OpenMx, with age used as a covariate.

resultsAnalyses including up to 162,469 individuals in 18,971 pedigrees estimated AUD prevalence at 5%-12% in men and 2%-5% in women. Results indicated substantial heritability (about 50%-60%), of which a portion upwards of 5% was attributable to the consequences of assortative mating. Contributions of shared environmental factors to AUD, which represent a mix of within- and cross-generational effects, appeared to be moderate (about 10%-20%). Unique environment accounted for the remaining variance (about 20%-30%). Sex differences in the magnitude of the variance components suggested higher heritability in men and correspondingly higher shared environmental contributions in women.

conclusionsUsing objective registry data, we found that AUD is highly heritable. Furthermore, shared environmental factors contributed significantly to the liability of AUD in both men and women.

Indexed as

AlcoholismChildFemaleHumansMalePedigreeRegistriesRisk FactorsSwedenTwins

Identifiers

PMID36971731
PMCPMC10364785
OpenAlexW4318773517

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.