Evidence map›Paper›PMID 36971555›Full record

ArticlemBio2023

Scaffold-Scaffold Interaction Facilitates Cell Polarity Development in Caulobacter crescentus.

Ning Lu, Samuel W Duvall, Guohong Zhao, Kimberley A Kowallis, Chao Zhang, Wei Tan, Jingxian Sun, Haley N Petitjean, Dylan T Tomares, Guo-Ping Zhao and 2 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. The polar landscape of bacterial pathogens and predators.Current opinion in microbiology · 2026
    Review
  2. A lipid cue drives the subcellular localization of a self-inserting bacterial transmembrane protein.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Ning Lu *CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Samuel W Duvall *Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Guohong ZhaoCAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Kimberley A KowallisDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Chao ZhangDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Wei TanCAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.ORCID 0000-0002-7832-9338
Jingxian SunCAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Haley N PetitjeanDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Dylan T TomaresDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Guo-Ping ZhaoCAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
W Seth ChildersDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Wei ZhaoCAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.ORCID 0000-0002-2422-8398
University of Pittsburgh · USChinese Academy of Sciences · CNHenan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell polarity development is the prerequisite for cell differentiation and generating biodiversity. In the model bacterium Caulobacter crescentus, the polarization of the scaffold protein PopZ during the predivisional cell stage plays a central role in asymmetric cell division. However, our understanding of the spatiotemporal regulation of PopZ localization remains incomplete. In the current study, a direct interaction between PopZ and the new pole scaffold PodJ is revealed, which plays a primary role in triggering the new pole accumulation of PopZ. The coiled-coil 4-6 domain in PodJ is responsible for interacting with PopZ

Indexed as

Caulobacter crescentusBacterial ProteinsCell CycleCell DifferentiationCell PolarityChromosome SegregationBacterial Proteinsasymmetric cell divisionCaulobacter crescentuscell polaritychromosome segregationPodJPopZscaffold proteins

Identifiers

PMID36971555
PMCPMC10127582
OpenAlexW4361001211

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.