Evidence map›Paper›PMID 36971349›Full record

ArticleMagnetic resonance in medicine2023

In vivo assessment of β-hydroxybutyrate metabolism in mouse brain using deuterium (

Narayan Datt Soni, Anshuman Swain, Paul Jacobs, Halvor Juul, Ryan Armbruster, Ravi Prakash Reddy Nanga, Kavindra Nath, Corinde Wiers, John Detre, Ravinder Reddy

Open access · bronzeAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Narayan Datt SoniDepartment of Radiology, Center for Advanced Metabolic Imaging in Precision Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-6436-7299
Anshuman SwainDepartment of Radiology, Center for Advanced Metabolic Imaging in Precision Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-0257-8610
Paul JacobsDepartment of Radiology, Center for Advanced Metabolic Imaging in Precision Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-3566-4010
Halvor JuulDepartment of Radiology, Center for Advanced Metabolic Imaging in Precision Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ryan ArmbrusterDepartment of Radiology, Center for Advanced Metabolic Imaging in Precision Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ravi Prakash Reddy NangaDepartment of Radiology, Center for Advanced Metabolic Imaging in Precision Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-3644-5656
Kavindra NathDepartment of Radiology, Center for Advanced Metabolic Imaging in Precision Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-3197-5703
Corinde WiersDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.ORCID 0000-0002-2934-8794
John DetreDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.ORCID 0000-0002-8115-6343
Ravinder ReddyDepartment of Radiology, Center for Advanced Metabolic Imaging in Precision Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-4580-2392
University of Pennsylvania · US

Funding

High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in HumansP41EB029460 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Ravinder Reddy · 2021 to 2026
$7.6M
In vivo Mapping of Muscle Specific MetabolismR01AG071725 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Ravinder Reddy · 2022 to 2026
$3.1M
Imaging of glutamatergic system changes in Alzheimer's disease in vivoR01AG063869 · NIA · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2020 to 2024
$3.0M
NIA NIH HHS R01 AG063869NIA NIH HHS R01AG063869NIA NIH HHS R01 AG071725NIA NIH HHS R01AG071725NIBIB NIH HHS P41 EB029460NIBIB NIH HHS P41EB029460
6 · The paper itself

Abstract

purposeTo monitor the metabolic turnover of β-hydroxybutyrate (BHB) oxidation using

methodsNine-month-old mice were infused with [3,4,4,4]-

resultsDeuterium label was incorporated into Glx from BHB metabolism through the tricarboxylic acid (TCA) cycle, with an increase in the level of [4,4]-

conclusion

Indexed as

Brain3-Hydroxybutyric AcidAnimalsDeuteriumMiceOxidation-Reduction3-Hydroxybutyric AcidDeuterium2H-MRSbraind4-BHBketone bodiesmetabolismTCA

Identifiers

PMID36971349
PMCPMC10662955
OpenAlexW4361017551

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.