Evidence map›Paper›PMID 36971062›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2023

The New p.F1700L LRRK2 Variant Causes Parkinson's Disease by Extensively Increasing Kinase Activity.

Max Borsche, Neringa Pratuseviciute, Susen Schaake, Frauke Hinrichs, Gabriel Morel, Jan Uter, Katja Lohmann, Christine Klein, Dario R Alessi, Johann Hagenah and 1 more

Abstract readCase ReportsLetter
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. medRxiv : the preprint server for health sciences · 2026
    Article
  3. Ex Vivo LRRK2 Activation in Asian G2385R and R1628P Variant Carriers and Idiopathic Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  4. Large-scale functional annotation establishes a reference framework for humanmedRxiv : the preprint server for health sciences · 2026
    Article
  5. Review
  6. Functional and Structural Characterization of LRRK2 p.V1447L in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Max BorscheInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.ORCID 0000-0002-9651-5986
Neringa PratuseviciuteMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Susen SchaakeInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Frauke HinrichsInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Gabriel MorelMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Jan UterInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Katja LohmannInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.ORCID 0000-0002-5121-1460
Christine KleinInstitute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Dario R AlessiMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Johann HagenahDepartment of Neurology, Westküstenklinikum Heide, Heide, Germany.
Esther SammlerMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, United Kingdom.ORCID 0000-0003-3218-7116

Funding

Chief Scientist Office SCAF/18/01Medical Research Council MC_UU_00018/1Medical Research Council MC_UU_12016/2
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Parkinson DiseaseHumansLeucine-Rich Repeat Serine-Threonine Protein Kinase-2MutationPhosphorylationLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, human

Identifiers

PMID36971062
PMCPMC10947214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.