ArticleCancer medicine2023
Clinical and pathological features analysis of invasive breast cancer with microcalcification.
Article in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Predictive value of multiparametric magnetic resonance imaging combined with pathological biomarkers for axillary lymph node metastasis of breast cancer.Gland surgery · 2025Article
- Tumor Hypoxia: How Conventional Histology Is Reshaped in Breast Carcinoma.International journal of molecular sciences · 2025Review
- Characterization of mammographic markers of inflammatory breast cancer (IBC).Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2025Article
- Intratumoral calcification seems like the tree rings for tumours such as oligodendroglioma.European radiology · 2024Article
- Clinical and pathological features analysis of invasive breast cancer with microcalcification.Cancer medicine · 2023Article
- Enhancing Specificity in Predicting Axillary Lymph Node Metastasis in Breast Cancer through an Interpretable Machine Learning Model with CEM and Ultrasound Integration.Technology in cancer research & treatmentArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMicrocalcification (MC) is a valuable diagnostic indicator to detect invasive breast cancer (IBC). This study aimed to determine the clinicopathological features of IBC with MC and detect biomarkers related to the potential mechanism of the MC formation in IBC.
methodsData from 364 patients with IBC were collected for the clinical characteristic analysis. The analysis of clinical data helped us to establish a predictive model of axillary node metastasis (ANM) before surgery. In addition, 49 tissue samples of IBC patients were collected to test the protein levels of osteocalcin (OCN) and hypoxia-inducible factor-1α (HIF-1α) by immunohistochemistry.
resultsSignificant differences were observed in tumor size, age, ANM, HER2
conclusionBased on this study, we concluded that patients with MC had a comparatively poor prognosis. MC was an independent predictive factor associated with the risk of ANM. High protein levels of OCN and HIF-1α were associated with MC and ANM, which were also related to poor prognosis. OCN and HIF-1α had a positive correlation in IBC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.