Evidence map›Paper›PMID 36970895›Full record

ArticleJournal of Alzheimer's disease : JAD2023

Investigating Compensatory Brain Activity in Older Adults with Subjective Cognitive Decline.

Christine Krebs, Esther Brill, Lora Minkova, Andrea Federspiel, Frauke Kellner-Weldon, Patric Wyss, Charlotte E Teunissen, Argonde C van Harten, Anna Seydell-Greenwald, Katharina Klink and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 4 countries.

Christine KrebsUniversity Hospital of Old Age Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Esther BrillUniversity Hospital of Old Age Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Lora MinkovaUniversity Hospital of Old Age Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Andrea FederspielTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Ber, Bern, Switzerland.
Frauke Kellner-WeldonSection Neuroradiology of the Department of Radiology, Cantonal Hospital Lucerne, Lucerne, Switzerland.
Patric WyssUniversity Hospital of Old Age Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Charlotte E TeunissenNeurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Vrije University, Amsterdam, the Netherlands.
Argonde C van HartenAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Anna Seydell-GreenwaldCenter for Brain Plasticity and Recovery, Georgetown University, Washington, DC, USA.
Katharina KlinkUniversity Hospital of Old Age Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Marc A ZüstUniversity Hospital of Old Age Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Anna-Katharine BremUniversity Hospital of Old Age Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Stefan KlöppelUniversity Hospital of Old Age Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
University of Bern · CHAmsterdam Neuroscience · NLGeorgetown University · USUniversity of Lucerne · CHVrije Universiteit Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreclinical Alzheimer's disease (AD) is one possible cause of subjective cognitive decline (SCD). Normal task performance despite ongoing neurodegeneration is typically considered as neuronal compensation, which is reflected by greater neuronal activity. Compensatory brain activity has been observed in frontal as well as parietal regions in SCD, but data are scarce, especially outside the memory domain.

objectiveTo investigate potential compensatory activity in SCD. Such compensatory activity is particularly expected in participants where blood-based biomarkers indicated amyloid positivity as this implies preclinical AD.

methods52 participants with SCD (mean age: 71.00±5.70) underwent structural and functional neuroimaging (fMRI), targeting episodic memory and spatial abilities, and a neuropsychological assessment. The estimation of amyloid positivity was based on plasma amyloid-β and phosphorylated tau (pTau181) measures.

resultsOur fMRI analyses of the spatial abilities task did not indicate compensation, with only three voxels exceeding an uncorrected threshold at p < 0.001. This finding was not replicated in a subset of 23 biomarker positive individuals.

conclusionOur results do not provide conclusive evidence for compensatory brain activity in SCD. It is possible that neuronal compensation does not manifest at such an early stage as SCD. Alternatively, it is possible that our sample size was too small or that compensatory activity may be too heterogeneous to be detected by group-level statistics. Interventions based on the individual fMRI signal should therefore be explored.

Indexed as

Alzheimer DiseaseCognitive DysfunctionAgedAmyloid beta-PeptidesBiomarkersBrainHumansMagnetic Resonance ImagingNeuropsychological TestsParietal LobeAmyloid beta-PeptidesBiomarkersBlood-based biomarkersepisodic memoryfunctional MRIneuronal compensationspatial abilitiessubjective cognitive decline

Identifiers

PMID36970895
PMCPMC10200167
OpenAlexW4328089986

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.