Evidence map›Paper›PMID 36970700›Full record

ArticleFrontiers in microbiology2023

Survival of

Lilja Brekke Thorfinnsdottir, Gaute Hovde Bø, James Alexander Booth, Per Bruheim

Full text read
In one paragraph

Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lilja Brekke ThorfinnsdottirDepartment of Biotechnology and Food Science, Norwegian University of Science and Technology, Trondheim, Norway.
Gaute Hovde BøDepartment of Biotechnology and Food Science, Norwegian University of Science and Technology, Trondheim, Norway.
James Alexander BoothDepartment of Microbiology, Oslo University Hospital, University of Oslo, Oslo, Norway.
Per BruheimDepartment of Biotechnology and Food Science, Norwegian University of Science and Technology, Trondheim, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The survival of bacterial cells exposed to antibiotics depends on the mode of action, the antibiotics concentration, and the duration of treatment. However, it also depends on the physiological state of the cells and the environmental conditions. In addition, bacterial cultures contain sub-populations that can survive high antibiotic concentrations, so-called persisters. Research on persisters is challenging due to multiple mechanisms for their formation and low fractions, down to and below one millionth of the total cell population. Here, we present an improved version of the persister assay used to enumerate the amount of persisters in a cell population. Methods: The persister assay with high antibiotic stress exposure was performed at both growth supporting and non-supporting conditions. Results: Survival of Discussion: The study provides guides and suggestions for the design of future experimentation in the research fields of persisters and antibiotic tolerance.

Indexed as

antibioticsbioreactorsEscherichia colimetabolite profilingmetabolomicspersistersrelA

Identifiers

PMID36970700
PMCPMC10036391

What OpenQuestion holds

Textfull text, public
LicenceCC BY
reference markers read10
measurements read71
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.