ArticleWorld journal of gastroenterology2023
Clinical features, diagnosis, and treatment of Peutz-Jeghers syndrome: Experience with 566 Chinese cases.
Article in World journal of gastroenterology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Diagnostic and therapeutic value of double-balloon enteroscopy in pediatric patients with Peutz-Jeghers syndrome.Translational pediatrics · 2026Article
- Peutz-Jeghers Syndrome and lung cancer: does the risk meet the threshold for lung cancer screening?Familial cancer · 2026Review
- Follow-up, cancer risk and mortality in Peutz-Jeghers syndrome: Data from the PRED-IdF network.European journal of human genetics : EJHG · 2026Article
- Familial pediatric Peutz-Jeghers syndrome with recurrent intussusception: case report and literature review.Frontiers in pediatrics · 2026Article
- Natural History of Rare Tumor Risk Syndromes: A Scoping Review to Inform Cost-Effectiveness Models.Journal of health economics and outcomes research · 2026Article
- [Colonoscopy in infants: procedure and disease spectrum analysis of 184 cases].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Natural surgical risks and age distribution in Chinese patients with Peutz-Jeghers syndrome: Real-world research based on a web survey.World journal of gastrointestinal surgery · 2025Article
- Rare large sigmoid hamartomatous polyp in an elderly patient with atypical Peutz-Jeghers syndrome: A case report.World journal of gastrointestinal surgery · 2025Article
- Genetic Investigation and Transcriptome Profiling in a Nuclear Family With Peutz-Jeghers Syndrome.Human mutation · 2025Article
- Intussusception secondary to Peutz-Jeghers syndrome: a case report and literature review of diagnostic and therapeutic advances.Frontiers in medicine · 2025Article
- Progress report: Peutz-Jeghers syndrome.Familial cancer · 2024Review
- [Current research status of Peutz-Jeghers syndrome in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Review
- Peutz-Jeghers syndrome: A case series.International journal of surgery case reports · 2024Article
- Preoperative multimodal ultrasonic imaging in a case of Peutz-Jeghers syndrome complicated by atypical lobular endocervical glandular hyperplasia: a case report and literature review.Hereditary cancer in clinical practice · 2024Article
- Cancer Risk of Peutz-Jeghers Syndrome and Treatment Experience: A Chinese Medical Center.Clinics in colon and rectal surgery · 2023Review
- Small Intestinal Polyp Burden in Pediatric Peutz-Jeghers Syndrome Assessed through Capsule Endoscopy: A Longitudinal Study.Children (Basel, Switzerland) · 2023Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeutz-Jeghers syndrome (PJS) is a clinically rare disease with pigmented spots on the lips and mucous membranes and extremities, scattered gastrointestinal polyps, and susceptibility to tumors as clinical manifestations. Effective preventive and curative methods are still lacking. Here we summarize our experience with 566 Chinese patients with PJS from a Chinese medical center with regard to the clinical features, diagnosis, and treatment.
aimTo explore the clinical features, diagnosis, and treatment of PJS in a Chinese medical center.
methodsThe diagnosis and treatment information of 566 cases of PJS admitted to the Air Force Medical Center from January 1994 to October 2022 was summarized. A clinical database was established covering age, gender, ethnicity, family history, age at first treatment, time and sequence of appearance of mucocutaneous pigmentation, polyp distribution, quantity, and diameter, frequency of hospitalization, frequency of surgical operations,
resultsOf all the patients included, 55.3% were male and 44.7% were female. Median time to the appearance of mucocutaneous pigmentation was 2 years, and median time from the appearance of mucocutaneous pigmentation to the occurrence of abdominal symptoms was 10 years. The vast majority (92.2%) of patients underwent small bowel endoscopy and treatment, with 2.3% having serious complications. There was a statistically significant difference in the number of enteroscopies between patients with and without canceration (
conclusionThe risk of intussusception and cancer of PJS polyps increases with age. PJS patients ≥ 10 years old should undergo annual enteroscopy. Endoscopic treatment has a good safety profile and can reduce the occurrence of polyps intussusception and cancer. Surgery should be conducted to protect the gastrointestinal system by removing polyps.
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