Evidence map›Paper›PMID 36970555›Full record

ReviewEngineering biology2021

Recent advances of integrated microfluidic suspension cell culture system.

Yi Jing Kerk, Aysha Jameel, Xin-Hui Xing, Chong Zhang

Abstract readReview
In one paragraph

Review in Engineering biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yi Jing KerkInstitute of Biochemical Engineering Department of Chemical Engineering, Tsinghua University Beijing China.
Aysha JameelInstitute of Biochemical Engineering Department of Chemical Engineering, Tsinghua University Beijing China.
Xin-Hui XingInstitute of Biochemical Engineering Department of Chemical Engineering, Tsinghua University Beijing China.
Chong ZhangInstitute of Biochemical Engineering Department of Chemical Engineering, Tsinghua University Beijing China.ORCID https://orcid.org/0000-0001-9609-8855

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microfluidic devices with superior microscale fluid manipulation ability and large integration flexibility offer great advantages of high throughput, parallelisation and multifunctional automation. Such features have been extensively utilised to facilitate cell culture processes such as cell capturing and culturing under controllable and monitored conditions for cell-based assays. Incorporating functional components and microfabricated configurations offered different levels of fluid control and cell manipulation strategies to meet diverse culture demands. This review will discuss the advances of single-phase flow and droplet-based integrated microfluidic suspension cell culture systems and their applications for accelerated bioprocess development, high-throughput cell selection, drug screening and scientific research to insight cell biology. Challenges and future prospects for this dynamically developing field are also highlighted.

Indexed as

bioMEMSbioprocess engineeringcellular biophysicsdropsdrugslab‐on‐a‐chipmicrobial synthesismicrofabricationmicrofluidicsoptimisationscreening strategiessuspensionssynthetic biology

Identifiers

PMID36970555
PMCPMC9996741

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.