Evidence map›Paper›PMID 36970542›Full record

ArticleFrontiers in neurology2023

Habituation deficit of visual evoked potentials in migraine patients with hypermobile Ehlers-Danlos syndrome.

Ilaria Maestrini, Lorenzo Rocchi, Francesca Puledda, Alessandro Viganò, Giada Giuliani, Tommaso Benedetto Jannini, Claudia Celletti, Marta Altieri, Filippo Camerota, Massimiliano Toscano and 1 more

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Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Ilaria MaestriniDepartment of Human Neurosciences, Headache Centre, "Sapienza" University of Rome, Rome, Italy.
Lorenzo RocchiDepartment of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Francesca PuleddaHeadache Group, Wolfson Centre for Age-Related Diseases (CARD), Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.
Alessandro ViganòDepartment of Human Neurosciences, Headache Centre, "Sapienza" University of Rome, Rome, Italy.
Giada GiulianiDepartment of Human Neurosciences, Headache Centre, "Sapienza" University of Rome, Rome, Italy.
Tommaso Benedetto JanniniDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Claudia CellettiPhysical Medicine and Rehabilitation Division, Umberto I Hospital, Rome, Italy.
Marta AltieriDepartment of Human Neurosciences, Headache Centre, "Sapienza" University of Rome, Rome, Italy.
Filippo CamerotaPhysical Medicine and Rehabilitation Division, Umberto I Hospital, Rome, Italy.
Massimiliano ToscanoDepartment of Human Neurosciences, Headache Centre, "Sapienza" University of Rome, Rome, Italy.
Vittorio Di PieroDepartment of Human Neurosciences, Headache Centre, "Sapienza" University of Rome, Rome, Italy.
Sapienza University of Rome · ITPoliclinico Umberto I · ITKing's College London · GBUniversity of Cagliari · ITUniversity of Pavia · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Migraine is one of the most frequent clinical manifestations of hypermobile Ehlers-Danlos syndrome (hEDS). The comorbidity between these two diseases has been only partially investigated. We aimed to observe whether neurophysiological alterations described in migraineurs in visual evoked potentials (VEPs) were present in hEDS patients with migraine. Methods: We enrolled 22 hEDS patients with migraine (hEDS) and 22 non-hEDS patients with migraine (MIG), with and without aura (according to ICHD-3), as well as 22 healthy controls (HC). Repetitive pattern reversal (PR)-VEPs were recorded in basal conditions in all participants. During uninterrupted stimulation, 250 cortical responses were recorded (4,000 Hz sample rate) and divided into epochs of 300 ms after the stimulus. Cerebral responses were divided into five blocks. The habituation was calculated as the slope interpolating the amplitudes in each block, for both the N75-P100 and P100-N145 components of PR-VEP. Results: We observed a significant habituation deficit of the P100-N145 component of PR-VEP in hEDS compared to HC ( Discussion: hEDS patients with migraine presented an interictal habituation deficit of both VEPs components like MIG. Pathophysiological aspects underlying the pathology could account for the peculiar pattern of habituation in hEDS patients with migraine characterized by a pronounced habituation deficit in the P100-N145 component and a less clear-cut habituation deficit in the N75-P100 component with respect to MIG.

Indexed as

Ehlers-Danlos syndromehabituation deficitmigraineneurophysiologyvisual evoked potential (VEP)

Identifiers

PMID36970542
PMCPMC10034036
OpenAlexW4323668114

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.