ReviewFrontiers in neurology2023
Diagnosis and treatment evaluation in patients with spontaneous intracranial hypotension.
Review in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Endovascular embolization of cerebrospinal fluid-venous fistula: a comprehensive systematic review on its efficacy and safety for the management of spontaneous intracranial hypotension.Neurosurgical review · 2024Pooled it
- Spontaneous intracranial hypotension with negative brain MRI findings: a systematic review of diagnostic strategies and clinical outcomes.Frontiers in neurologyPooled it
- Frequency and characteristics of multi-domain autonomic dysfunction in patients with spontaneous intracranial hypotension.Headache · 2026Article
- Automated Aqueductal CSF Flow Analysis in Spontaneous Intracranial Hypotension: Hemodynamic Quantification and Exploratory Waveform Morphology Assessment Using Cine PC-MRI.Diagnostics (Basel, Switzerland) · 2026Article
- Caffeine and Headache: Exploring the Multifaceted Relationship.Brain and behavior · 2026Review
- Article
- Altered brain fluid dynamics in spontaneous intracranial hypotension.Fluids and barriers of the CNS · 2025Observational
- Assessing the effects of spontaneous intracranial hypotension on quality of life, work ability and disability.Wiener klinische Wochenschrift · 2025Article
- Intracranial pressure monitoring in patients with spontaneous onset of orthostatic headache.The journal of headache and pain · 2025Observational
- Intracranial hypotension headache complicated by retroclival subdural hematoma: clinical insights and literature review.Frontiers in neuroscience · 2025Article
- Optic Nerve Sheath MR Imaging Measurements in Patients with Orthostatic Headaches and Normal Findings on Conventional Imaging Predict the Presence of an Underlying CSF-Venous Fistula.AJNR. American journal of neuroradiology · 2024Article
- Don't delay, but don't despair: symptom duration, comorbidity and outcome after closure of spinal cerebrospinal fluid leaks.Journal of neurology · 2024Article
- More than a headache-somatic and mental symptom burden in spontaneous intracranial hypotension before and after surgical treatment.Frontiers in neurology · 2024Article
- Case report: Simultaneous measurement of intracranial pressure and lumbar intrathecal pressure during epidural patch therapy for treating spontaneous intracranial hypotension syndrome. Spontaneous intracranial hypotension or spontaneous intraspinal hypovolume?Frontiers in neurology · 2024Article
- Evaluation and management of orthostatic headache in hypermobility disorders.Frontiers in neurology · 2023Review
- Reversible cerebral vasoconstriction syndrome following intracranial hypotension in a postpartum patient: a case report and literature review.Frontiers in neurology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spontaneous intracranial hypotension is characterized by an orthostatic headache and audiovestibular symptoms alongside a myriad of other non-specific symptoms. It is caused by an unregulated loss of cerebrospinal fluid at the spinal level. Indirect features of CSF leaks are seen on brain imaging as signs of intracranial hypotension and/or CSF hypovolaemia as well as a low opening pressure on lumbar puncture. Direct evidence of CSF leaks can frequently, but not invariably, be observed on spinal imaging. The condition is frequently misdiagnosed due to its vague symptoms and a lack of awareness of the condition amongst the non-neurological specialities. There is also a distinct lack of consensus on which of the many investigative and treatment options available to use when managing suspected CSF leaks. The aim of this article is to review the current literature on spontaneous intracranial hypotension and its clinical presentation, preferred investigation modalities, and most efficacious treatment options. By doing so, we hope to provide a framework on how to approach a patient with suspected spontaneous intracranial hypotension and help minimize diagnostic and treatment delays in order to improve clinical outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.