Evidence map›Paper›PMID 36970457›Full record

ArticleJournal of traditional and complementary medicine2023

Calebin-A prevents HFD-induced obesity in mice by promoting thermogenesis and modulating gut microbiota.

Pei-Sheng Lee, Ying-Ying Lu, Kalyanam Nagabhushanam, Chi-Tang Ho, Hui-Ching Mei, Min-Hsiung Pan

Open access · diamondAbstract read
In one paragraph

Article in Journal of traditional and complementary medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. Review
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  8. Review
  9. Article
  10. Foods (Basel, Switzerland) · 2023
    Article
  11. Editorial note: Gut microbiota and health.Journal of traditional and complementary medicine · 2023
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Pei-Sheng LeeInstitute of Food Science and Technology, National Taiwan University, Taipei, 10617, Taiwan.
Ying-Ying LuDepartment of Natural Science Education, National Taipei University of Education, Taipei, Taiwan.
Kalyanam NagabhushanamSabinsa Corporation, East Windsor, NJ, 08520, USA.
Chi-Tang HoDepartment of Food Science, Rutgers University, New Brunswick, NJ, 08901, USA.
Hui-Ching MeiDepartment of Natural Science Education, National Taipei University of Education, Taipei, Taiwan.
Min-Hsiung PanInstitute of Food Science and Technology, National Taiwan University, Taipei, 10617, Taiwan.
National Taipei University of Education · TWAsia University · TWNational Taiwan University · TWRutgers, The State University of New Jersey · USSabin Vaccine Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aim: Obesity is one of the complications of sedentary lifestyle and high-calorie food intake which become a global problem. Thermogenesis is a novel way to promote anti-obesity by consuming energy as heat rather than storing it as triacylglycerols. Over the last decade, growing evidence has identified the gut microbiota as a potential factor in the pathophysiology of obesity. Calebin A is a non-curcuminoid novel compound derived from the rhizome of medicinal turmeric with putative anti-obesity effects. However, its ability on promoting thermogenesis and modulating gut microbiota remain unclear. Experimental procedure: C57BL/6J mice were fed either normal diet or high-fat diet (HFD) supplement with calebin A (0.1 and 0.5%) diet for 12 weeks. The composition of the gut microbiota was assessed by analyzing 16S rRNA gene sequences. Results and conclusion: Mice treated with calebin A shows a remarkable alteration in microbiota composition compared with that of normal diet-fed or HFD-fed mice and is characterized by an enrichment of

Indexed as

Anti-ObesityCalebin AGut microbiotaObesityThermogenesis

Identifiers

PMID36970457
PMCPMC10037069
OpenAlexW4205307655

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.