Evidence map›Paper›PMID 36970371›Full record

ArticlePhosphorus, sulfur, and silicon and the related elements2022

A study on the cellular and cytotoxic effects of S and Se heterocycles on the myeloid leukemia cell line PLB-985.

Niccole Auld, Krystal Flood, Tanay Kesharwani, Peter J Cavnar

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Phosphorus, sulfur, and silicon and the related elements, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Niccole AuldDepartment of Biology, University of West Florida, 11000 University Pkwy, Pensacola, FL, USA.
Krystal FloodDepartment of Biology, University of West Florida, 11000 University Pkwy, Pensacola, FL, USA.
Tanay KesharwaniDepartment of Chemistry, University of West Florida, 11000 University Pkwy, Pensacola, FL, USA.
Peter J CavnarDepartment of Biology, University of West Florida, 11000 University Pkwy, Pensacola, FL, USA.
University of West Florida · US

Funding

MARC at University of West FloridaT34GM110517 · NIGMS · UNIVERSITY OF WEST FLORIDA · PI CAVNAR, PETER J., MOLEK, KAREN SINCLAIR · 2014 to 2023
$2.6M
NIGMS NIH HHS T34 GM110517
6 · The paper itself

Abstract

This paper describes the synthesis of several halogenated S and Se heterocycles and tests their biological activity by measuring the effects on the myeloid leukemia cell line, PLB-985 cells. We report that select compounds exhibit significant increases in mitochondria membrane potential and increased oxidative stress in PLB-985 cells. Our results contribute to the foundational knowledge of different S and Se containing compounds and their possible impacts on human cells.

Indexed as

benzo[b]selenophenebenzo[b]thiophenemitochondria membrane potentialoxidative stressselenophenethiophene

Identifiers

PMID36970371
PMCPMC10035560
OpenAlexW4281731894

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.