ArticleFrontiers in psychiatry2023
Breaking the vicious cycle: The interplay between loneliness, metabolic illness, and mental health.
Article in Frontiers in psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Non-alcoholic fatty liver disease and coexisting depression, anxiety and/or stress in adults: a systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Possible osteosarcopenia is associated with loss in intrinsic capacity and early cognitive deficits: a longitudinal study of older adults in Singapore.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- The joint association of loneliness, social isolation, and satisfaction with major depressive disorder incidence in individuals with diabetes.Endocrine · 2026Article
- The contribution of social and economic factors to accelerated biological aging differences between non-Hispanic Black and White adults in the Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Generalized anxiety and loneliness among the general population in Saudi Arabia.BMC psychiatry · 2026Article
- The case for space as a model of accelerated aging.Nature aging · 2026Review
- Social rank and social environment combinedly affect REM sleep in mice.Scientific reports · 2026Article
- Loneliness and sarcopenia in aged care: the mediating role of fatigability.Innovation in aging · 2026Article
- Clinical relevance of loneliness in the treatment of depression: study protocol for a naturalistic prospective longitudinal study.Frontiers in psychiatry · 2026Article
- Knowledge-practice concordance and discrepancies in very old adults.Frontiers in medicine · 2026Article
- Social bonds and health: exploring the impact of social relations on oxytocin and brain-gut communication in shaping obesity.Gut microbes · 2025Article
- The prevalence and influence of self-reported loneliness in the older with community-acquired pneumonia: a multi-center cohort study.BMC geriatrics · 2025Article
- Hormonal and Behavioral Consequences of Social Isolation and Loneliness: Neuroendocrine Mechanisms and Clinical Implications.International journal of molecular sciences · 2025Review
- Current Strategies for Healthy Aging: The Interplay Between Nutrition, Metabolism, and Exercise.Cureus · 2025Review
- Caring While Moving: Case Studies on Physical Activity and Dementia Caregiver Well-Being.Healthcare (Basel, Switzerland) · 2025Article
- Explainable machine learning model incorporating social determinants of health to predict chronic kidney disease in type 2 diabetes patients.Journal of diabetes and metabolic disorders · 2025Article
- Experiences of Social Isolation in Older Adults with Chronic Diseases: A Qualitative Study Based on Patients' Perspectives.Healthcare (Basel, Switzerland) · 2025Article
- CORR Insights®: Are Levels of Loneliness Associated With Levels of Comfort and Capability in Musculoskeletal Illness?Clinical orthopaedics and related research · 2025Article
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Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Loneliness, or perceived social isolation, is a leading predictor of all-cause mortality and is increasingly considered a public health epidemic afflicting significant portions of the general population. Chronic loneliness is itself associated with two of the most pressing public health epidemics currently facing the globe: the rise of mental illness and metabolic health disorders. Here, we highlight the epidemiological associations between loneliness and mental and metabolic health disorders and argue that loneliness contributes to the etiology of these conditions by acting as a chronic stressor that leads to neuroendocrine dysregulation and downstream immunometabolic consequences that manifest in disease. Specifically, we describe how loneliness can lead to overactivation of the hypothalamic-pituitary-adrenal axis and ultimately cause mitochondrial dysfunction, which is implicated in mental and metabolic disease. These conditions can, in turn, lead to further social isolation and propel a vicious cycle of chronic illness. Finally, we outline interventions and policy recommendations that can reduce loneliness at both the individual and community levels. Given its role in the etiology of the most prevalent chronic diseases of our time, focusing resources on alleviating loneliness is a vitally important and cost-effective public health strategy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.