Evidence map›Paper›PMID 36970224›Full record

ArticleKidney medicine2023

CKD Progression Risk and Subsequent Cause of Death: A Population-Based Cohort Study.

Nayanjot K Rai, Zheng Wang, Paul E Drawz, John Connett, Daniel P Murphy

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06046261 (Exploring the Impact of " ACP Board Game for Life" on Death Preparation and Anxiety in Patients With Stage 4 and 5 Chronic Kidney Diseases), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06046261 nacompletednot on this map

Exploring the Impact of " ACP Board Game for Life" on Death Preparation and Anxiety in Patients With Stage 4 and 5 Chronic Kidney Diseases: A Pilot Study

TypeinterventionalSponsorNational Cheng-Kung University HospitalRan2022 to 2023Enrolled69ConditionsChronic Kidney Disease, Chronic Renal Failure, Chronic Renal Insufficiency, End of Life CareArmsACP board game for life
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Adverse Muscle Composition Is Associated with All-Cause Mortality in CKD: A UK Biobank Imaging Study.Clinical journal of the American Society of Nephrology : CJASN · 2026
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  11. Review
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  17. Undiagnosed Coronary Artery Disease in Hemodialysis-Initiating Patients.Journal of atherosclerosis and thrombosis · 2025
    Article
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nayanjot K RaiDivision of Nephrology and Hypertension, University of Minnesota Medical School, Minneapolis, Minnesota.
Zheng WangDivision of Biostatistics, University of Minnesota School of Public Health, Minneapolis, Minnesota.
Paul E DrawzDivision of Nephrology and Hypertension, University of Minnesota Medical School, Minneapolis, Minnesota.
John ConnettDivision of Biostatistics, University of Minnesota School of Public Health, Minneapolis, Minnesota.
Daniel P MurphyDivision of Nephrology and Hypertension, University of Minnesota Medical School, Minneapolis, Minnesota.
University of Minnesota Medical Center · USUniversity of Minnesota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rationale & Objective: Chronic kidney disease (CKD) is a prevalent condition with high mortality rates. Cardiovascular disease (CVD) is accepted as the leading cause of death in CKD, but data are limited, and no study has evaluated the cause of death in those with progressive CKD versus stable kidney function. Study Design: Retrospective cohort. Setting & Participants: Adults receiving primary care at M Health Fairview (MHFV) after December 31, 2012, with linked Minnesota Death Index data before December 31, 2019, were included. A second cohort was created from adult participants in the 1996-2006 National Health and Nutrition Examination Survey (NHANES) linked with the National Death Index through 2015. Individuals with kidney replacement therapy at baseline were excluded. Exposures: Estimated glomerular filtration rate (eGFR) and proteinuria assessed at baseline defined the exposure categories for MHFV and NHANES. CKD progression in MHFV was also defined as an eGFR decrease ≥30% from baseline or incident kidney replacement therapy. Outcome: CVD-, malignancy-, and dementia-attributed death. Analytical Approach: Multinomial logistic regression. Results: For both cohorts, CVD death was more common than malignancy death for those with eGFR <60 mL/min/1.73 m Limitations: Limited follow-up and, for MHFV, nonprotocolized measures of kidney function were limitations, as were the intrinsic accuracy limitations for death certificates. Conclusions: CVD death is the most significant cause of death observed for those with a reduced eGFR irrespective of CKD progression.

Indexed as

Cardiovascular diseasecause of deathchronic kidney diseaseeGFR

Identifiers

PMID36970224
PMCPMC10034498
OpenAlexW4317693727

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.