Evidence map›Paper›PMID 36970203›Full record

ArticleActa pharmaceutica Sinica. B2023

Mucus-penetrating nonviral gene vaccine processed in the epithelium for inducing advanced vaginal mucosal immune responses.

Qunjie Bi, Xu Song, Yangyang Zhao, Xueyi Hu, Huan Yang, Rongrong Jin, Yu Nie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qunjie BiNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610041, China.
Xu SongNMPA Key Laboratory for Quality Research and Control of Tissue Regenerative Biomaterial & Institute of Regulatory Science for Medical Devices & NMPA Research Base of Regulatory Science for Medical Devices, Sichuan University, Chengdu 610041, China.
Yangyang ZhaoNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610041, China.
Xueyi HuNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610041, China.
Huan YangNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610041, China.
Rongrong JinNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610041, China.
Yu NieNational Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610041, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Establishment of vaginal immune defenses at the mucosal interface layer through gene vaccines promise to prevent infectious diseases among females. Mucosal barriers composed of a flowing mucus hydrogel and tightly conjugated epithelial cells (ECs), which represent the main technical difficulties for vaccine development, reside in the harsh, acidic human vaginal environment. Different from frequently employed viral vectors, two types of nonviral nanocarriers were designed to concurrently overcome the barriers and induce immune responses. Differing design concepts include the charge-reversal property (DRLS) to mimic a virus that uses any cells as factories, as well as the addition of a hyaluronic acid coating (HA/RLS) to directly target dendritic cells (DCs). With a suitable size and electrostatic neutrality, these two nanoparticles penetrate a mucus hydrogel with similar diffusivity. The DRLS system expressed a higher level of the carried human papillomavirus type 16 L1 gene compared to HA/RLS

Indexed as

Epithelial processingIntravaginal gene deliveryLipopeptideMucus penetrationNonviral gene vaccinationpH-sensitiveVirus mimicking

Identifiers

PMID36970203
PMCPMC10031263

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.