Evidence map›Paper›PMID 36970170›Full record

ArticleNeuro-oncology practice2023

Five-year survivors from brain metastases treated with stereotactic radiosurgery: Biology, improving treatments, or just plain luck?

Jane B Pearce, Fang-Chi Hsu, Claire M Lanier, Christina K Cramer, Jimmy Ruiz, Hui-Wen Lo, Fei Xing, Margaret Smith, Wencheng Li, Christopher Whitlow and 4 more

Open access · greenAbstract read
In one paragraph

Article in Neuro-oncology practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Auxiliary Value of [Cancers · 2025
    Article
  2. Article
  3. Article
  4. Treatment Options for Brain Metastases.Current treatment options in oncology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Jane B PearceDepartment of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA.ORCID https://orcid.org/0000-0001-5743-5249
Fang-Chi HsuDepartment of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Claire M LanierDepartment of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Christina K CramerDepartment of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Jimmy RuizDepartment of Medicine (Hematology and Oncology), Wake Forest School of Medicine, Winston-Salem, NC, USA.
Hui-Wen LoDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Fei XingDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Margaret SmithDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Wencheng LiDepartment of Pathology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Christopher WhitlowDepartment of Pathology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Jaclyn J WhiteDepartment of Neurosurgery, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Stephen B TatterDepartment of Neurosurgery, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Adrian W LaxtonDepartment of Neurosurgery, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Michael D ChanDepartment of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Wake Forest University · US

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
NCI NIH HHS P30 CA012197
6 · The paper itself

Abstract

Background: Improvements in therapies have led to an increasing number of long-term survivors of brain metastases. The present series compares a population of 5-year survivors of brain metastases to a generalized brain metastases population to assess for factors attributable to long-term survival. Methods: A single institution retrospective review was performed to identify 5-year survivors of brain metastases who received stereotactic radiosurgery (SRS). A historical control population of 737 patients with brain metastases was used to assess similarities and differences between the long-term survivor population and the general population treated with SRS. Results: A total of 98 patients with brain metastases were found to have survived over 60 months. No differences between long-term survivors and controls were identified with regards to the age at first SRS ( Conclusion: Five-year survivors of brain metastases represent a diverse histologic population, suggesting a small population of oligometastatic and indolent cancers exist for each cancer type.

Indexed as

brain metastasisneurologic deathprolonged survival

Identifiers

PMID36970170
PMCPMC10037943
OpenAlexW4311303643

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.