Evidence map›Paper›PMID 36970153›Full record

ArticleRSC medicinal chemistry2023

Design and synthesis of naturally-inspired SARS-CoV-2 inhibitors.

Haitham Hassan, Jeanne Chiavaralli, Afnan Hassan, Loay Bedda, Tim Krischuns, Kuang-Yu Chen, Alice Shi Ming Li, Adrien Delpal, Etienne Decroly, Masoud Vedadi and 5 more

Open access · greenAbstract read
In one paragraph

Article in RSC medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 3 countries.

Haitham HassanInstitut Pasteur, Department of Structural Biology and Chemistry, CNRS UMR no 3523 Chem4Life, Epigenetic Chemical Biology, Université Paris Cité F-75015 Paris France ibnel.haitham.hassan@gmail.com paola.arimondo@cnrs.fr.ORCID https://orcid.org/0000-0001-7982-3074
Jeanne ChiavaralliInstitut Pasteur, Center for Technological Resources and Research (C2RT), CNRS UMR no 3523 Chem4Life, Chemogenomic and Biological Screening platform, Université Paris Cité F-75015 Paris France.ORCID https://orcid.org/0000-0001-9135-4565
Afnan HassanDrug Design and Discovery Lab, Zewail City of Science and Technology 12578 Cairo Egypt rkhidr@zewailcity.edu.eg.ORCID https://orcid.org/0000-0001-8434-4449
Loay BeddaDrug Design and Discovery Lab, Zewail City of Science and Technology 12578 Cairo Egypt rkhidr@zewailcity.edu.eg.ORCID https://orcid.org/0000-0002-5751-3857
Tim KrischunsInstitut Pasteur, Unité Biologie des ARN et Virus Influenza, CNRS UMR3569, Université Paris Cité F-75015 Paris France.ORCID https://orcid.org/0000-0003-2693-4701
Kuang-Yu ChenInstitut Pasteur, Unité Biologie des ARN et Virus Influenza, CNRS UMR3569, Université Paris Cité F-75015 Paris France.
Alice Shi Ming LiDepartment of Pharmacology and Toxicology, University of Toronto Canada.ORCID https://orcid.org/0000-0003-1093-9698
Adrien DelpalCNRS - UMR7257 - AFMB - Aix-Marseille Université Marseille France.ORCID https://orcid.org/0000-0003-0598-7679
Etienne DecrolyCNRS - UMR7257 - AFMB - Aix-Marseille Université Marseille France.
Masoud VedadiDepartment of Pharmacology and Toxicology, University of Toronto Canada.ORCID https://orcid.org/0000-0002-0574-0169
Nadia NaffakhInstitut Pasteur, Unité Biologie des ARN et Virus Influenza, CNRS UMR3569, Université Paris Cité F-75015 Paris France.ORCID https://orcid.org/0000-0002-0424-0277
Fabrice AgouInstitut Pasteur, Center for Technological Resources and Research (C2RT), CNRS UMR no 3523 Chem4Life, Chemogenomic and Biological Screening platform, Université Paris Cité F-75015 Paris France.
Sergio MallartInstitut Pasteur, Department of Structural Biology and Chemistry, CNRS UMR no 3523 Chem4Life, Epigenetic Chemical Biology, Université Paris Cité F-75015 Paris France ibnel.haitham.hassan@gmail.com paola.arimondo@cnrs.fr.ORCID https://orcid.org/0000-0003-1846-8683
Reem K ArafaDrug Design and Discovery Lab, Zewail City of Science and Technology 12578 Cairo Egypt rkhidr@zewailcity.edu.eg.ORCID https://orcid.org/0000-0001-7527-1655
Paola B ArimondoInstitut Pasteur, Department of Structural Biology and Chemistry, CNRS UMR no 3523 Chem4Life, Epigenetic Chemical Biology, Université Paris Cité F-75015 Paris France ibnel.haitham.hassan@gmail.com paola.arimondo@cnrs.fr.ORCID https://orcid.org/0000-0001-5175-4396
Centre National de la Recherche Scientifique · FRZewail City of Science and Technology · EGUniversity of Toronto · CA

Funding

Targeting Viroporins and Coronavirus M ProteinU19AI171110 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nevan J Krogan · 2022 to 2026
$103.4M
NIAID NIH HHS U19 AI171110
6 · The paper itself

Abstract

A naturally inspired chemical library of 25 molecules was synthesised guided by 3-D dimensionality and natural product likeness factors to explore a new chemical space. The synthesised chemical library, consisting of fused-bridged dodecahydro-2

Identifiers

PMID36970153
PMCPMC10034039
OpenAlexW4319989181

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.