Evidence map›Paper›PMID 36970143›Full record

ArticleRSC medicinal chemistry2023

Host-guest binding of tetracationic cyclophanes to photodynamic agents inhibits posttreatment phototoxicity and maintains antitumour efficacy.

Jian-Da Sun, Yamin Liu, Zijian Zhao, Shang-Bo Yu, Qiao-Yan Qi, Wei Zhou, Hui Wang, Ke Hu, Dan-Wei Zhang, Zhan-Ting Li

Open access · greenAbstract read
In one paragraph

Article in RSC medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. A Bioorthogonal Antidote Against the Photosensitivity after Photodynamic Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jian-Da SunDepartment of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University 2205 Songhu Road Shanghai 200438 China zhangdw@fudan.edu.cn ztli@fudan.edu.cn.
Yamin LiuDepartment of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University 2205 Songhu Road Shanghai 200438 China zhangdw@fudan.edu.cn ztli@fudan.edu.cn.ORCID https://orcid.org/0000-0001-7344-1788
Zijian ZhaoDepartment of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University 2205 Songhu Road Shanghai 200438 China zhangdw@fudan.edu.cn ztli@fudan.edu.cn.
Shang-Bo YuKey Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 345 Lingling Lu Shanghai 200032 China yushbo@sioc.ac.cn.ORCID https://orcid.org/0000-0001-7186-367X
Qiao-Yan QiKey Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 345 Lingling Lu Shanghai 200032 China yushbo@sioc.ac.cn.
Wei ZhouDepartment of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University 2205 Songhu Road Shanghai 200438 China zhangdw@fudan.edu.cn ztli@fudan.edu.cn.ORCID https://orcid.org/0000-0001-7467-3628
Hui WangDepartment of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University 2205 Songhu Road Shanghai 200438 China zhangdw@fudan.edu.cn ztli@fudan.edu.cn.
Ke HuDepartment of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University 2205 Songhu Road Shanghai 200438 China zhangdw@fudan.edu.cn ztli@fudan.edu.cn.ORCID https://orcid.org/0000-0002-0240-7192
Dan-Wei ZhangDepartment of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University 2205 Songhu Road Shanghai 200438 China zhangdw@fudan.edu.cn ztli@fudan.edu.cn.ORCID https://orcid.org/0000-0003-1244-1850
Zhan-Ting LiDepartment of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University 2205 Songhu Road Shanghai 200438 China zhangdw@fudan.edu.cn ztli@fudan.edu.cn.ORCID https://orcid.org/0000-0003-3954-0015
Fudan University · CNChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the past two decades, photodynamic therapy (PDT) has become an effective method for the treatment of cancer. However, the posttreatment residue of photodynamic agents (PDAs) causes long-term skin phototoxicity. Here, we apply naphthalene-derived, box-like tetracationic cyclophanes, named NpBoxes, to bind to clinically used porphyrin-based PDAs to alleviate their posttreatment phototoxicity by reducing their free content in skin tissues and

Identifiers

PMID36970143
PMCPMC10034117
OpenAlexW4319349970

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.