ArticleChemical science2023
Enantioselective direct Michael addition of cyanohydrin ether derivatives to enones catalyzed by chiral bis(guanidino)iminophosphorane organosuperbase.
Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Vapor-Phase Deposition of CsPbBrSmall (Weinheim an der Bergstrasse, Germany) · 2026Article
- Bridging Synthesis and Device Performance in Perovskite Quantum Dot Light-Emitting Diodes.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Construction of 1,3-Nonadjacent Stereogenic Centers Through Enantioselective Addition of α-Thioacetamides to α-Substituted Vinyl Sulfones Catalyzed by Chiral Strong Brønsted Base.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
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Authors and funding
3 authors.
Funding
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Abstract
The direct use of cyanohydrin ether derivatives as less acidic pronucleophiles was achieved for the first time in the catalytic enantioselective Michael addition reaction under transition metal free conditions. Chiral bis(guanidino)iminophosphoranes as the higher order organosuperbase facilitated the intended catalytic Michael addition to enones, giving rise to the corresponding products in high yields with moderate to high diastereo- and enantioselectivities in most cases. Further elaboration of the corresponding enantioenriched product was conducted by derivatization into a lactam derivative through hydrolysis followed by cyclo-condensation.
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