Evidence map›Paper›PMID 36970052›Full record

ArticleCancer research communications2022

Mansoor Raza Mirza, Gabriel Lindahl, Sven Mahner, Andrés Redondo, Michel Fabbro, Bobbie J Rimel, Jørn Herrstedt, Amit M Oza, Ulrich Canzler, Jonathan S Berek and 10 more

Registry-linked trialOpen access · goldFull text read
In one paragraph

Article in Cancer research communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01847274 (A Phase 3 Randomized Double-blind Trial of Maintenance With Niraparib Versus Placebo in Patients With Platinum Sensitive Ovarian Cancer.), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01847274 phase3completednot on this map

A Phase 3 Randomized Double-blind Trial of Maintenance With Niraparib Versus Placebo in Patients With Platinum Sensitive Ovarian Cancer.

TypeinterventionalSponsorTesaro, Inc.Ran2013 to 2021Enrolled596ConditionsOvarian Neoplasms, Platinum Sensitive Ovarian CancerArmsActive comparator: Niraparib, placebo
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Cancers · 2024
    Review
  6. Article
  7. Review
  8. Is Reflex GermlineCancers · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 18 institutions in 9 countries.

Mansoor Raza MirzaNordic Society of Gynaecological Oncology (NSGO) and Department of Oncology Rigshospitalet-Copenhagen University Hospital, Copenhagen, Denmark.
Gabriel LindahlNordic Society of Gynaecological Oncology (NSGO) and Department of Oncology, Linköping University Hospital, Linköping, Sweden.
Sven MahnerArbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe (AGO) and Department of Gynecology and Gynecologic Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-0640-129X
Andrés RedondoGrupo Español de Investigación en Cáncer de Ovario (GEICO) and Department of Medical Oncology, Hospital Universitario La Paz-IdiPAZ, Madrid, Spain.
Michel FabbroICM Val d'Aurelle Parc Euromedecine, Oncologie Médicale, Montpellier, GINECO, Paris, France.ORCID 0000-0003-1910-4777
Bobbie J RimelCedars-Sinai Cancer, Cedars-Sinai Medical Center, Los Angeles, California.
Jørn HerrstedtDepartment of Clinical Oncology and Palliative Care Zealand University Hospital Roskilde and Næstved, University of Copenhagen, Copenhagen, Denmark.
Amit M OzaDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.ORCID 0000-0002-9510-8641
Ulrich CanzlerArbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe (AGO) and Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Jonathan S BerekStanford University School of Medicine and Stanford Cancer Institute, Stanford, California.
Antonio González-MartínMedical Oncology Department, Clínica Universidad de Navarra, Madrid, Program in Solid Tumors, Center for Applied Medical Research (CIMA), Pamplona, Spain, Grupo Español de Investigación en Cáncer de Ovario (GEICO), Madrid, Spain.ORCID 0000-0001-8376-9576
Phillipe FollanaCentre Antoine Lacassagne, Nice, France.ORCID 0000-0001-6999-462X
Rosemary LordMedical Oncology, Clatterbridge Cancer Centre NHS Foundation Trust, Bebington, United Kingdom.
Masoud AzodiDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut.
Kasey EstensonGSK, Philadelphia, Pennsylvania.
Zebin WangGSK, Waltham, Massachusetts.
Yong LiGSK, Waltham, Massachusetts.
Divya GuptaGSK, Waltham, Massachusetts.
Ursula MatulonisDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.ORCID 0000-0002-3103-6992
Bin FengGSK, Waltham, Massachusetts.ORCID 0000-0001-6186-0061
BG Medicine (United States) · USPolicy Analysis (United States) · USBoston Medical Center · USCedars-Sinai Medical Center · USCentre Antoine Lacassagne · FRClatterbridge Cancer Centre NHS Foundation Trust · GBClinica Universidad de Navarra · ESEuromedic · PLGlaxoSmithKline (United States) · USLinköping University · SENational Center for Tumor Diseases · DENordic Society of Gynecologic Oncology · DKPrincess Margaret Cancer Centre · CASpanish Ovarian Cancer Research Group · ESStanford University · USUniversität Hamburg · DEYale University · USZealand University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this analysis, we examined the relationship between progression-free survival (PFS) and mutation status of 18 homologous recombination repair (HRR) genes in patients in the non-germline Significance: We retrospectively evaluated the mutational profile of HRR genes in tumor samples from 331 patients from the non-germline

Indexed as

Ovarian NeoplasmsCarcinoma, Ovarian EpithelialFemaleHumansIndazolesNeoplasm Recurrence, LocalPiperidinesRecombinational DNA RepairRetrospective StudiesIndazolesniraparibPiperidines

Identifiers

PMID36970052
PMCPMC10035404
OpenAlexW4307638653

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read36
identifiers read1
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.