ArticleBrain communications2023
Structural MRI predicts clinical progression in presymptomatic genetic frontotemporal dementia: findings from the GENetic Frontotemporal dementia Initiative cohort.
Open access · goldFull text read
In one paragraph
Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- The Differential Effects of Genetic Mutations in ALS and FTD Genes on Behavioural and Cognitive Changes: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- Quantifying multimodal longitudinal brain changes in presymptomatic C9orf72 disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Human TDP-43 expression worsens FTD-related phenotypes in progranulin-insufficient mice.Neurobiology of disease · 2026Article
- Temporal order of clinical, imaging, and biomarker changes in frontotemporal lobar degeneration-associated syndromes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Advanced diffusion MRI tract signatures in Alzheimer's disease, dementia with Lewy bodies, and the FTD/PPA spectrum.NeuroImage · 2026Review
- Changes in body composition in genetic C9orf72 carriers: The role of the hypothalamus and thalamus.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Composite grey matter fingerprints for genetic frontotemporal dementia.Journal of neurology, neurosurgery, and psychiatry · 2026Article
- CSF protein biomarkers are associated with atrophy and symptom severity in genetic FTD: a GENFI study.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- The effect of human-specific genetic variants on neuronal spinogenesis.Frontiers in genetics · 2026Review
- Label tree semantic losses for rich multi-class medical image segmentation.Frontiers in artificial intelligence · 2026Article
- Cortical microstructure is associated with disease severity and clinical progression in genetic frontotemporal dementia: a GENFI study.Molecular psychiatry · 2025Article
- Structural and functional connectivity in tau mutation carriers: from presymptomatic to symptomatic frontotemporal dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Thalamus involvement in genetic frontotemporal dementia assessed using structural and diffusion MRI: a GENFI study.Brain communications · 2025Article
- Microstructural grey matter alterations in patients with behavioural variant frontotemporal dementia.Brain communications · 2025Article
- Genomic Insights into Dementia: Precision Medicine and the Impact of Gene-Environment Interaction.Aging and disease · 2024Review
- Characterization of Progranulin Gene Mutations in Portuguese Patients with Frontotemporal Dementia.International journal of molecular sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
39 authors at 20 institutions in 11 countries.
Martina BocchettaDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.ORCID https://orcid.org/0000-0003-1814-5024
Emily G ToddDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.ORCID https://orcid.org/0000-0003-1551-5691
Arabella BouziguesDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
David M CashDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.ORCID https://orcid.org/0000-0001-7833-616X
Jennifer M NicholasDepartment of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Rhian S ConveryDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
Lucy L RussellDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
David L ThomasDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
Ian B MaloneDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.ORCID https://orcid.org/0000-0001-7512-7856
Juan Eugenio IglesiasCentre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.
John C van SwietenDepartment of Neurology and Alzheimer center, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
Lize C JiskootDepartment of Neurology and Alzheimer center, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0002-1120-1858
Harro SeelaarDepartment of Neurology and Alzheimer center, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0003-1989-7527
Barbara BorroniCentre for Neurodegenerative Disorders, Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.ORCID https://orcid.org/0000-0001-9340-9814
Daniela GalimbertiDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
Raquel Sanchez-ValleNeurology Department, Hospital Clinic, Institut d'Investigacions Biomèdiques, Barcelona, Spain.ORCID https://orcid.org/0000-0001-7750-896X
Robert LaforceClinique Interdisciplinaire de Mémoire, Département des Sciences Neurologiques, CHU de Québec, Faculté de Médecine, Université Laval, Quebec City, QC, Canada.
Fermin MorenoHospital Universitario Donostia, San Sebastian, Spain.
Matthis SynofzikDivision Translational Genomics of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Tübingen, Germany.ORCID https://orcid.org/0000-0002-2280-7273
Caroline GraffDepartment NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-9949-2951
Mario MasellisCampbell Cognitive Neurology Research Unit, Sunnybrook Research Institute, Toronto, ON, Canada.
Maria Carmela TartagliaToronto Western Hospital, Tanz Centre for Research in Neurodegenerative Disease, Toronto, ON, Canada.
James B RoweDepartment of Clinical Neurosciences and Cambridge University Hospitals NHS Trust and Medical Research Council Cognition and brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom.
Rik VandenbergheLaboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0001-6237-2502
Elizabeth FingerDepartment of Clinical Neurological Sciences, University of Western Ontario, London, ON, Canada.
Fabrizio TagliaviniFondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Neurologico Carlo Besta, Milan, Italy.
Alexandre de MendonçaFaculty of Medicine, University of Lisbon, Lisbon, Portugal.
Isabel SantanaNeurology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
Chris R ButlerDepartment of Clinical Neurology, University of Oxford, Oxford, United Kingdom.
Simon DucharmeDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.ORCID https://orcid.org/0000-0002-7309-1113
Alexander GerhardDivision of Neuroscience and Experimental Psychology, Wolfson Molecular Imaging Centre, University of Manchester, Manchester, United Kingdom.ORCID https://orcid.org/0000-0002-8071-6062
Adrian DanekNeurologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, Germany.ORCID https://orcid.org/0000-0001-8857-5383
Johannes LevinNeurologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, Germany.
Markus OttoDepartment of Neurology, University Hospital Ulm, Ulm, Germany.
Sandro SorbiDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Isabelle Le BerSorbonne Université, Paris Brain Institute-Institut du Cerveau- ICM, Inserm U1127, CNRS UMR 7225, AP-HP-Hôpital Pitié-Salpêtrière, Paris, France.
Florence PasquierUniversity Lille, Lille, France.ORCID https://orcid.org/0000-0001-9880-9788
Jonathan D RohrerDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
Genetic Frontotemporal dementia Initiative (GENFI)
UK Dementia Research Institute · GBErasmus MC · NLGerman Center for Neurodegenerative Diseases · DEHospitais da Universidade de Coimbra · PTKarolinska University Hospital · SEBiogipuzkoa Health Research Institute · ESCentre National de la Recherche Scientifique · FRDon Carlo Gnocchi Foundation · ITFondazione IRCCS Istituto Neurologico Carlo Besta · ITHarvard University · USInserm · FRKlinik und Poliklinik für Neurologie · DEKU Leuven · BELondon School of Hygiene & Tropical Medicine · GBMcGill University · CAMRC Cognition and Brain Sciences Unit · GBSunnybrook Health Science Centre · CAToronto Western Hospital · CAUniversité Laval · CAUniversity Hospital Ulm · DE
Funding
Medical Research Council MR/M008525/1Medical Research Council MR/T046015/1Wellcome Trust 103838
Abstract
Biomarkers that can predict disease progression in individuals with genetic frontotemporal dementia are urgently needed. We aimed to identify whether baseline MRI-based grey and white matter abnormalities are associated with different clinical progression profiles in presymptomatic mutation carriers in the GENetic Frontotemporal dementia Initiative. Three hundred eighty-seven mutation carriers were included (160
Indexed as
brain volumetrydiffusion imaginggenetic frontotemporal dementiaMRI imagingpresymptomatic stage
Identifiers
What OpenQuestion holds
Textfull text, public
LicenceCC BY
measurements read12
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.