Evidence map›Paper›PMID 36970045›Full record

ArticleBrain communications2023

Cognitive correlates of antisaccade behaviour across multiple neurodegenerative diseases.

Heidi C Riek, Donald C Brien, Brian C Coe, Jeff Huang, Julia E Perkins, Rachel Yep, Paula M McLaughlin, Joseph B Orange, Alicia J Peltsch, Angela C Roberts and 35 more

Full text read
In one paragraph

Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Reflexive eye movement alterations are related to subclinical impulsive-compulsive behaviors in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  5. Observational
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  7. Article
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  10. Ocular changes as potential biomarkers for early diagnosis of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
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  13. Article
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors.

Heidi C RiekCentre for Neuroscience Studies, Queen's University, Kingston, Ontario K7L 3N6Canada.ORCID https://orcid.org/0000-0002-9966-4047
Donald C BrienCentre for Neuroscience Studies, Queen's University, Kingston, Ontario K7L 3N6Canada.ORCID https://orcid.org/0000-0002-4074-6646
Brian C CoeCentre for Neuroscience Studies, Queen's University, Kingston, Ontario K7L 3N6Canada.
Jeff HuangCentre for Neuroscience Studies, Queen's University, Kingston, Ontario K7L 3N6Canada.
Julia E PerkinsCentre for Neuroscience Studies, Queen's University, Kingston, Ontario K7L 3N6Canada.
Rachel YepCentre for Neuroscience Studies, Queen's University, Kingston, Ontario K7L 3N6Canada.ORCID https://orcid.org/0000-0001-6716-8973
Paula M McLaughlinNova Scotia Health, Halifax, Nova Scotia B3S 0H6, Canada.
Joseph B OrangeSchool of Communication Sciences and Disorders, Faculty of Health Sciences, Western University, London, Ontario N6G 1H1, Canada.
Alicia J PeltschFaculty of Engineering and Applied Science, Queen's University, Kingston Ontario K7L 3N6, Canada.
Angela C RobertsSchool of Communication Sciences and Disorders, Faculty of Health Sciences, Western University, London, Ontario N6G 1H1, Canada.
Malcolm A BinnsRotman Research Institute, Baycrest Centre, North York, Ontario M6A 2E1, Canada.
Wendy LouDalla Lana School of Public Health, University of Toronto, Toronto, Ontario M5T 3M7, Canada.
Agessandro AbrahaoDivision of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario M5S 3H2, Canada.ORCID https://orcid.org/0000-0003-1142-2842
Stephen R ArnottRotman Research Institute, Baycrest Centre, North York, Ontario M6A 2E1, Canada.
Derek BeatonRotman Research Institute, Baycrest Centre, North York, Ontario M6A 2E1, Canada.
Sandra E BlackDivision of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario M5S 3H2, Canada.
Dar DowlatshahiDepartment of Medicine (Neurology), University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
Elizabeth FingerDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 3K7, Canada.
Corinne E FischerKeenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario M5B 1W8, Canada.
Andrew R FrankDepartment of Medicine (Neurology), University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
David A GrimesDepartment of Medicine (Neurology), University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
Sanjeev KumarCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario M6J 1H4, Canada.
Anthony E LangDivision of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario M5S 3H2, Canada.
Jane M Lawrence-DewarThunder Bay Regional Health Research Institute, Thunder Bay, Ontario P7B 7A5, Canada.
Jennifer L MandziaDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 3K7, Canada.
Connie MarrasDivision of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario M5S 3H2, Canada.
Mario MasellisHurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario M4N 3M5, Canada.ORCID https://orcid.org/0000-0002-6244-2096
Stephen H PasternakDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 3K7, Canada.
Bruce G PollockCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario M6J 1H4, Canada.
Tarek K RajjiDepartment of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Demetrios J SahlasDepartment of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.
Gustavo SaposnikDivision of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario M5S 3H2, Canada.
Dallas P SeitzDepartment of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
Christen ShoesmithDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 3K7, Canada.
Thomas D L SteevesDivision of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario M5S 3H2, Canada.
Stephen C StrotherRotman Research Institute, Baycrest Centre, North York, Ontario M6A 2E1, Canada.
Kelly M SunderlandRotman Research Institute, Baycrest Centre, North York, Ontario M6A 2E1, Canada.
Richard H SwartzDivision of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario M5S 3H2, Canada.
Brian TanRotman Research Institute, Baycrest Centre, North York, Ontario M6A 2E1, Canada.
David F Tang-WaiDivision of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario M5S 3H2, Canada.
Maria Carmela TartagliaUniversity Health Network Memory Clinic, Krembil Brain Institute, Toronto Western Hospital, Toronto, Ontario M5T 2S8, Canada.
John TurnbullDepartment of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.
Lorne ZinmanDivision of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario M5S 3H2, Canada.
Douglas P MunozCentre for Neuroscience Studies, Queen's University, Kingston, Ontario K7L 3N6Canada.ORCID https://orcid.org/0000-0001-5362-8203
ONDRI Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oculomotor tasks generate a potential wealth of behavioural biomarkers for neurodegenerative diseases. Overlap between oculomotor and disease-impaired circuitry reveals the location and severity of disease processes via saccade parameters measured from eye movement tasks such as prosaccade and antisaccade. Existing studies typically examine few saccade parameters in single diseases, using multiple separate neuropsychological test scores to relate oculomotor behaviour to cognition; however, this approach produces inconsistent, ungeneralizable results and fails to consider the cognitive heterogeneity of these diseases. Comprehensive cognitive assessment and direct inter-disease comparison are crucial to accurately reveal potential saccade biomarkers. We remediate these issues by characterizing 12 behavioural parameters, selected to robustly describe saccade behaviour, derived from an interleaved prosaccade and antisaccade task in a large cross-sectional data set comprising five disease cohorts (Alzheimer's disease/mild cognitive impairment, amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease, and cerebrovascular disease;

Indexed as

antisaccadecognitive impairmentdementianeurodegenerative diseaseprosaccade

Identifiers

PMID36970045
PMCPMC10036290

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.