Evidence map›Paper›PMID 36970008›Full record

ArticleWorld journal of clinical cases2023

Patients with hepatocellular carcinoma that die during the first year of liver transplantation have high blood sFasL concentrations.

Leonardo Lorente, Sergio T Rodriguez, Pablo Sanz, Agustín F González-Rivero, Antonia Pérez-Cejas, Javier Padilla, Dácil Díaz, Antonio González, María M Martín, Alejandro Jiménez and 3 more

Open access · diamondAbstract read
In one paragraph

Article in World journal of clinical cases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Leonardo LorenteIntensive Care Unit, Hospital Universitario de Canarias, La Laguna 38320, Spain. lorentemartin@msn.com.
Sergio T RodriguezIntensive Care Unit, Hospital Universitario Nuestra Señora Candelaria, Santa Cruz Tenerife 38010, Spain.
Pablo SanzDepartment of Surgery, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz Tenerife 38010, Spain.
Agustín F González-RiveroDepartment of Laboratory, Hospital Universitario de Canarias, La Laguna 38320, Spain.
Antonia Pérez-CejasDepartment of Laboratory, Hospital Universitario de Canarias, La Laguna 38320, Spain.
Javier PadillaDepartment of Surgery, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz Tenerife 38010, Spain.
Dácil DíazDepartment of Digestive, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz Tenerife 38010, Spain.
Antonio GonzálezDepartment of Digestive, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz Tenerife 38010, Spain.
María M MartínIntensive Care Unit, Hospital Universitario Nuestra Señora Candelaria, Santa Cruz Tenerife 38010, Spain.
Alejandro JiménezResearch Unit, Hospital Universitario de Canarias, La Laguna 38320, Spain.
Purificación CerroTransplant Unit, Hospital Universitario Nuestra Señora Candelaria, Santa Cruz Tenerife 38010, Spain.
Julián PorteroDepartment of Radiology, Hospital Universitario Nuestra Señora Candelaria, Santa Cruz Tenerife 38010, Spain.
Manuel A BarreraDepartment of Surgery, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz Tenerife 38010, Spain.
Hospital Universitario de Canarias · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFas ligand (FasL) is one ligand that activates extrinsic apoptosis pathway. High expression in lymphocytes of FasL have been found in patients with acute rejection of liver transplantation (LT). No high blood concentrations of soluble FasL (sFasL) have been found in patients with acute LT rejection; however, the samples size of those studies was small.

aimTo determine whether patients with hepatocellular carcinoma (HCC) that dead during the first year of LT have higher blood sFasL concentrations previously to LT that those who that remain alive in a study of higher sample size.

methodsPatients underwent LT due to HCC were included in this retrospective study. Serum sFasL levels prior to LT were measured and one-year LT mortality was registered.

resultsNon-surviving patients (

conclusionWe report for the first time that HCC patients who die within the first year of HT have higher blood sFasL concentrations prior to HT than those who remain alive.

Indexed as

Hepatocellular carcinomaLiver transplantationMortalityOutcomesFasL

Identifiers

PMID36970008
PMCPMC10037289
OpenAlexW4323304728

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.