ArticleFrontiers in nutrition2023
Sodium acetate regulates milk fat synthesis through the activation of GPR41/GPR43 signaling pathway.
Article in Frontiers in nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 16 citations in OpenAlex.
- Maternal purified fiber supplementation-enriched Akkermansia muciniphila regulates lactation and offspring growth via the gut-mammary axis.Science China. Life sciences · 2026Article
- Short-Chain Fatty Acids (SCFAs) Modulate the Hepatic Glucose and Lipid Metabolism ofInternational journal of molecular sciences · 2025Article
- Glutamate increases the lean percentage and intramuscular fat content and alters gut microbiota in Shaziling pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
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9 authors at 2 institutions in 1 country.
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Abstract
Background: Fat is a critical component in milk, which provided energy for the early growth and development of mammals. Milk fat is positively related to the concentration of acetate in the blood, while the underlying mechanism is still unclear. Objective: This study is to investigate the effects of sodium acetate (NaAc) on milk fat synthesis in the mammary gland, and explored the underlying mechanism. Methods: Results: In this study, we found that NaAc promoted milk fat synthesis and the expression of related genes and proteins in HC11 mammary epithelial cells with the activation of GPCR and mTORC1 signaling pathways ( Conclusion: The addition of NaAc promoted the increase of milk fat synthesis in HC11 mammary epithelial cells and mice mammary glands at peak lactation. Mechanistically, NaAc activates GPR41 and GPR43 receptors, leading to the activation of the mTORC1 signaling pathway to promote the synthesis of milk fat.Graphical abstract.
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