Evidence map›Paper›PMID 36969704›Full record

ArticleAtherosclerosis plus2023

Associations of urinary isoprostanes with measures of subclinical atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA).

Ryan L Wallace, Oluseye Ogunmoroti, Di Zhao, Dhananjay Vaidya, Amir Heravi, Eliseo Guallar, Chiadi E Ndumele, Joao A C Lima, Pamela Ouyang, Matthew J Budoff and 6 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis plus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005487 (Multi-Ethnic Study of Atherosclerosis), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 68% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00005487 active not recruitingnot on this map

Multi-Ethnic Study of Atherosclerosis (MESA)

TypeobservationalSponsorNational Heart, Lung, and Blood Institute (NHLBI)Ran1999 to 2030Enrolled6,418ConditionsAtherosclerosis, Cardiovascular Diseases, Heart Diseases, Coronary Artery Disease
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Ryan L WallaceDepartment of Cardiology, MedStar Washington Hospital Center, Washington, DC, USA.
Oluseye OgunmorotiDivision of Cardiology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Di ZhaoDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Dhananjay VaidyaDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Amir HeraviDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Eliseo GuallarDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Chiadi E NdumeleDivision of Cardiology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Joao A C LimaDivision of Cardiology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Pamela OuyangDivision of Cardiology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Matthew J BudoffLundquist Institute, Division of Cardiology, University of California Los Angeles, Los Angeles, CA, USA.
Matthew AllisonDivision of Preventive Medicine, Department of Family Medicine, University of California San Diego, San Diego, CA, USA.
Isac ThomasDivision of Preventive Medicine, Department of Family Medicine, University of California San Diego, San Diego, CA, USA.
Oluwaseun E FashanuSands Constellation Heart Institute, Rochester Regional Health, Rochester, NY, USA.
Ron HoogeveenDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.
Wendy S PostDivision of Cardiology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Erin D MichosDivision of Cardiology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · USUniversity of California San Diego · USBaylor College of Medicine · USMedStar Washington Hospital Center · USUnity Health System · USUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Urinary isoprostanes are markers of systemic oxidative stress, which is implicated in the pathogenesis of atherosclerotic cardiovascular disease (ASCVD). Coronary artery calcium (CAC), thoracic aortic calcium (TAC) and carotid plaque are measure subclinical atherosclerosis and prognosticate ASCVD risk. We examined the associations between urinary isoprostane levels and measures of plaque prevalence, burden, incidence and progression across three vascular beds in a cohort from the Multi-Ethnic Study of Atherosclerosis. Methods: Urinary levels of 8-isoprostane and 2,3-dinor-8-F Results: In adjusted models, there were no significant associations between isoprostane levels with CAC prevalence or progression. Highest versus lowest tertile of 8-isoprostane was associated with 28% lower prevalence of descending TAC at baseline [prevalence ratio (PR) 0.72 95% CI (0.56, 0.94)], while 1-SD higher 2,3-dinor-8-F Conclusions: Higher urinary isoprostanes were inconsistently associated with some measures of subclinical atherosclerosis by imaging. This suggests a limited role of urinary isoprostane levels as a prognostic marker for the development of ASCVD. Trial registration: The MESA cohort design is registered at clinicaltrials.gov as follows: https://clinicaltrials.gov/ct2/show/NCT00005487.

Identifiers

PMID36969704
PMCPMC10037087
OpenAlexW4313216553

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.