Evidence map›Paper›PMID 36969580›Full record

ArticleFrontiers in physiology2023

Normalizing salt content by mixing native human airway mucus samples normalizes sample rheology.

Matthew R Markovetz, Jacob E Hibbard, Lucas M Plott, Lawrence G Bacudio, William J Kissner, Andrew Ghio, Priya A Kumar, Harendra Arora, David B Hill

Open access · goldFull text read
In one paragraph

Article in Frontiers in physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Matthew R MarkovetzMarsico Lung Institute, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Jacob E HibbardMarsico Lung Institute, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Lucas M PlottMarsico Lung Institute, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Lawrence G BacudioMarsico Lung Institute, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
William J KissnerMarsico Lung Institute, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Andrew GhioNational Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Chapel Hill, NC, United States.
Priya A KumarDepartment of Anesthesiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Harendra AroraDepartment of Anesthesiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
David B HillMarsico Lung Institute, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
University of North Carolina at Chapel Hill · USLung Institute · USEnvironmental Protection Agency · USNorth Carolina State University · USOutcomes Research Consortium · US

Funding

Project 4: Biophysical and structural characterization of airway submucosal gland mucus in health and diseaseP01HL164320 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Richard Charles Boucher, Michael Rubinstein · 2022 to 2026
$13.9M
NHLBI NIH HHS P01 HL164320
6 · The paper itself

Abstract

Across the globe, millions of people are affected by muco-obstructive pulmonary diseases like cystic fibrosis, asthma, and chronic obstructive pulmonary disease. In MOPDs, the airway mucus becomes hyperconcentrated, increasing viscoelasticity and impairing mucus clearance. Research focused on treatment of MOPDs requires relevant sources of airway mucus both as a control sample type and as a basis for manipulation to study the effects of additional hyperconcentration, inflammatory milieu, and biofilm growth on the biochemical and biophysical properties of mucus. Endotracheal tube mucus has been identified as a prospective source of native airway mucus given its several advantages over sputum and airway cell culture mucus such as ease of access and

Indexed as

airway physiologymuco-obstructive pulmonary diseasesmucusmucus rheologyparticle tracking microrheology

Identifiers

PMID36969580
PMCPMC10036356
OpenAlexW4323858777

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read37
identifiers read1
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.