Evidence map›Paper›PMID 36969560›Full record

ArticleMolecular therapy oncolytics2023

Multi-modal efficacy of a chimeric vesiculovirus expressing the Morreton glycoprotein in sarcoma.

Chelsae R Watters, Oumar Barro, Natalie M Elliott, Yumei Zhou, Musa Gabere, Elizabeth Raupach, Alexander T Baker, Michael T Barrett, Kenneth H Buetow, Bertram Jacobs and 3 more

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy oncolytics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Chelsae R WattersDivision of Hematology/Oncology, Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA.
Oumar BarroDivision of Hematology/Oncology, Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA.
Natalie M ElliottDivision of Hematology/Oncology, Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA.
Yumei ZhouDivision of Hematology/Oncology, Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA.
Musa GabereDivision of Hematology/Oncology, Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA.
Elizabeth RaupachDivision of Hematology/Oncology, Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA.
Alexander T BakerAccession Therapeutics, Oxford OX4 2JZ, UK.
Michael T BarrettDivision of Hematology/Oncology, Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA.
Kenneth H BuetowComputational Sciences and Informatics Program for Complex Adaptive System Arizona State University, Tempe, AZ 85281, USA.
Bertram JacobsCenter for Infectious Diseases and Vaccinology, the Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA.
Mahesh SeetharamDivision of Hematology/Oncology, Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA.
Mitesh J BoradDivision of Hematology/Oncology, Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA.
Bolni Marius NagaloDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Mayo Clinic in Arizona · USMayo Clinic · USArizona State University · USWinthrop Rockefeller Foundation · US

Funding

Project 4: ImmunovirotherapyP50CA210964 · NCI · MAYO CLINIC ROCHESTER · PI Zongming Eric Chen · 2018 to 2026
$20.5M
Paul Calabresi Program in Clinical/Translational Research at Mayo ClinicK12CA090628 · NCI · MAYO CLINIC ROCHESTER · PI WEROHA, SARAVUT · 2001 to 2025
$19.7M
Oncolytic Virotherapy in Hepatocellular CancerDP2CA195764 · NCI · MAYO CLINIC ARIZONA · PI BORAD, MITESH · 2014 to 2016
$2.7M
cGAS-STING Pathway Targeting Replicative Adenoviruses with CD46 Tropism and AFP Promoter Conditional Replication Restriction for the Treatment of Hepatocellular CarcinomaK01CA234324 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI NAGALO, BOLNI MARIUS · 2018 to 2022
$667k
NCI NIH HHS DP2 CA195764NCI NIH HHS K01 CA234324NCI NIH HHS K12 CA090628NCI NIH HHS P50 CA210964
6 · The paper itself

Abstract

Vesiculoviruses are attractive oncolytic virus platforms due to their rapid replication, appreciable transgene capacity, broad tropism, limited preexisting immunity, and tumor selectivity through type I interferon response defects in malignant cells. We developed a synthetic chimeric virus (VMG) expressing the glycoprotein (G) from Morreton virus (MorV) and utilizing the remaining structural genes from vesicular stomatitis virus (VSV). VMG exhibited

Indexed as

Morreton virusoncolyticssarcomavesiculovirusvirotherapy

Identifiers

PMID36969560
PMCPMC10033453
OpenAlexW4322621308

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.