Evidence map›Paper›PMID 36969433›Full record

ArticleACS omega2023

Development of Terahertz Imaging Markers for Pancreatic Ductal Adenocarcinoma using Maximum

Debamitra Chakraborty, Bradley N Mills, Jing Cheng, Ivan Komissarov, Scott A Gerber, Roman Sobolewski

Open access · goldFull text read
In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Debamitra ChakrabortyMaterials Science Graduate Program, University of Rochester, Rochester, New York 14627-1299, USA.ORCID https://orcid.org/0000-0002-4651-2437
Bradley N MillsDepartment of Surgery, University of Rochester Medical Center, Rochester, New York 14642, USA.
Jing ChengMaterials Science Graduate Program, University of Rochester, Rochester, New York 14627-1299, USA.
Ivan KomissarovLaboratory for Laser Energetics, University of Rochester, Rochester, New York 14623, USA.
Scott A GerberDepartment of Surgery, University of Rochester Medical Center, Rochester, New York 14642, USA.
Roman SobolewskiMaterials Science Graduate Program, University of Rochester, Rochester, New York 14627-1299, USA.
Energetics (United States) · USUniversity of Rochester Medical Center · US

Funding

Development of a New Strategy to Treat Locally Advanced Pancreatic CancerR01CA230277 · NCI · UNIVERSITY OF ROCHESTER · PI GERBER, SCOTT ANDREW · 2019 to 2023
$2.0M
Repolarizing the Tumor and Metastatic Microenvironments to Treat Patients with Pancreatic CancerR01CA262580 · NCI · UNIVERSITY OF ROCHESTER · PI GERBER, SCOTT ANDREW, LINEHAN, DAVID C · 2021 to 2025
$1.6M
NCI NIH HHS R01 CA230277
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the significant reasons for cancer-related death in the United States due to a lack of timely prognosis and the poor efficacy of the standard treatment protocol. Immunotherapy-based neoadjuvant therapy, such as stereotactic body radiotherapy (SBRT), has shown promising results compared to conventional radiotherapy in strengthening the antitumor response in PDAC. To probe and quantify the antitumor response with SBRT, we propose to study the tumor microenvironment using terahertz time-domain spectroscopy (THz-TDS). Since the tumor's complex microenvironment plays a key role in disease progression and treatment supervision, THz-TDS can be a revolutionary tool to help in treatment planning by probing the changes in the tissue microenvironment. This paper presents THz-TDS of paraffin-embedded PDAC samples utilizing a clinically relevant genetically engineered mouse model. This Article aims to develop and validate a novel time-domain approximation method based on maximum

Identifiers

PMID36969433
PMCPMC10034990
OpenAlexW4323542998

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read3
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.