ArticleFrontiers in immunology2023
The causality between intestinal flora and allergic diseases: Insights from a bi-directional two-sample Mendelian randomization analysis.
Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 2 of them syntheses that pooled it.
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Who cites it
65 citing papers in PubMed, 2 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- The Emerging Role of Gut Microbiota in Inflammatory Skin Diseases: A Systematic Review.Experimental dermatology · 2026Pooled it
- Gut microbiome alterations and their clinical and biological implications in ovarian cancer: a systematic review.Frontiers in oncology · 2025Pooled it
- Genetically mediated causal relationship between gut microbiota composition and childhood obesity.Pediatric research · 2026Article
- Causal relationship between gut microbiome and childhood allergy: A bidirectional Mendelian randomization analysis.Medicine · 2026Article
- The gut microbial profile and circulating metabolism are associated with functional constipation in children.Pediatric research · 2026Article
- Machine learning identifies differences between breast milk and formula in the gut microbiome.Gut microbiome (Cambridge, England) · 2026Article
- Deciphering the gut microbiota's role in infection risk: Mendelian randomization analysis of microbial taxa and infectious outcomes.Frontiers in microbiology · 2026Article
- Mendelian randomization studies in atopic dermatitis: causal insights across omics layers.Frontiers in immunology · 2026Review
- Article
- A New Perspective on Nasal Microbiota Dysbiosis-Mediated Allergic Rhinitis: From the Mechanism of Immune Microenvironment Remodeling to Microbiota-Targeted Therapeutic Strategies.International journal of molecular sciences · 2025Review
- Exploration of the mechanism of intestinal flora-mediated immune modulation in the pathogenesis of gout.Clinical rheumatology · 2025Article
- Characterization of intestinal microbiota in patients with psoriasis combined with metabolic syndrome.Molecular and cellular biochemistry · 2025Article
- Article
- Mendelian randomization analysis reveals causal relationship between allergic diseases and influenza.The World Allergy Organization journal · 2025Article
- Gut microbiome impact on childhood allergic rhinitis and house dust mite IgE responses.Pediatric research · 2025Article
- Differential responses of lung and intestinal microbiota to SARS-CoV-2 infection: a comparative study of the Wuhan and Omicron strains in K18-hACE2 Tg mice.Laboratory animal research · 2025Article
- [Causal association between gut microbiota and food allergy: a Mendelian randomization analysis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Causal relationship between gut microbiota and malignant lymphoma: a two-way two-sample mendelian randomization study.Translational cancer research · 2025Article
- Two-Sample Mendelian Randomization Analyses Identified Lipid Species Associated With Intracranial Aneurysm Formation.Brain and behavior · 2025Article
- Multi-omics in Allergic Rhinitis: Mechanism Dissection and Precision Medicine.Clinical reviews in allergy & immunology · 2025Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Growing evidence shows a significant association between intestinal flora and allergic diseases, specifically atopic dermatitis (AD), allergic rhinitis (AR), and allergic asthma (AA). However, the causality has not yet been clarified. Objective: We conducted a bidirectional two-sample Mendelian randomization (TSMR) analysis to study the causal relationships between intestinal flora classification and AD, AR, or AA. Materials and methods: We obtained summary data of intestinal flora, AD, AR, and AA from a genome-wide association research. The inverse-variance weighted method is the primary method for analyzing causality in the TSMR analysis. Several sensitivity analyses were conducted to examine the stability of TSMR results. Reverse TSMR analysis was also performed to assess whether there was a reverse causality. Results: A total of 7 bacterial taxa associated with AD, AR, and AA were identified by the current TSMR analysis. Specifically, the genus Dialister( Conclusion: We confirmed the causal relationship between intestinal flora and allergic diseases and provided an innovative perspective for research on allergic diseases: targeted regulation of dysregulation of specific bacterial taxa to prevent and treat AD, AR, and AA.
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