ArticleFrontiers in immunology2023
Causal relationships between gut microbiota and programmed cell death protein 1/programmed cell death-ligand 1: A bidirectional Mendelian randomization study.
Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Mendelian randomization analysis revealed a gut microbiota-eye axis in acute anterior uveitis.Eye (London, England) · 2025Article
- Depression reduces cognitive function partly through effects on BMI and hypertension: a large observational study and Mendelian randomization analysis.BMC psychiatry · 2025Observational
- Causal correlations between inflammatory proteins and heart failure: A two-sample Mendelian randomization analysis.ESC heart failure · 2025Article
- Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword.Cancer cell international · 2025Review
- Investigating the correlation between gut microbiota and prostate cancer through a two-sample Mendelian randomization analysis.Medicine · 2025Article
- PD-L1 deficiency exacerbates colitis severity by remodeling gut microbiota in inflammatory bowel disease.Frontiers in immunology · 2025Article
- Causal Relationship Between Depression, Sleep Disorders, and Constipation: A Mendelian Randomization and Mediation Analysis.Psychology research and behavior management · 2025Article
- Recurrent aphthous stomatitis and neoplasms of the mouth and pharynx: a two-sample Mendelian randomization study.BMC cancer · 2024Article
- Investigating the causal role of the gut microbiota in esophageal cancer and its subtypes: a two-sample Mendelian randomization study.BMC cancer · 2024Article
- The role of circulating cytokines in heart failure: a bidirectional, two-sample Mendelian randomization study.Frontiers in cardiovascular medicine · 2024Article
- Causal relationships between gut microbiome and obstructive sleep apnea: a bi-directional Mendelian randomization.Frontiers in microbiology · 2024Article
- Endometriosis is a disease of immune dysfunction, which could be linked to microbiota.Frontiers in genetics · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Multiple clinical studies have indicated that the gut microbiota influences the effects of immune checkpoint blockade (ICB) therapy comprising PD-1/PD-L1 inhibitors, but the causal relationship is unclear. Because of numerous confounders, many microbes related to PD-1/PD-L1 have not been identified. This study aimed to determine the causal relationship between the microbiota and PD-1/PD-L1 and identify possible biomarkers for ICB therapy. Method: We used bidirectional two-sample Mendelian randomization with two different thresholds to explore the potential causal relationship between the microbiota and PD-1/PD-L1 and species-level microbiota GWAS to verify the result. Result: In the primary forward analysis, genus_Holdemanella showed a negative correlation with PD-1 [βIVW = -0.25; 95% CI (-0.43 to -0.07); P
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