Evidence map›Paper›PMID 36969190›Full record

ReviewFrontiers in immunology2023

Tissue-resident memory T cells in gastrointestinal tumors: turning immune desert into immune oasis.

Mengjie Liang, Xingzhou Wang, Daming Cai, Wenxian Guan, Xiaofei Shen

Full text readReview
In one paragraph

Review in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
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  9. CD69Cell communication and signaling : CCS · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mengjie LiangDepartment of General Surgery, Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
Xingzhou WangDepartment of General Surgery, Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
Daming CaiDepartment of General Surgery, Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
Wenxian GuanDepartment of General Surgery, Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
Xiaofei ShenDepartment of General Surgery, Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue-resident memory T cells (Trm) are a particular type of T cell subgroup, which stably reside in tissues and have been revealed to be the most abundant memory T cell population in various tissues. They can be activated in the local microenvironment by infection or tumor cells and rapidly clean them up to restore homeostasis of local immunity in gastrointestinal tissues. Emerging evidence has shown that tissue-resident memory T cells have great potential to be mucosal guardians against gastrointestinal tumors. Therefore, they are considered potential immune markers for immunotherapy of gastrointestinal tumors and potential extraction objects for cell therapy with essential prospects in clinical translational therapy. This paper systematically reviews the role of tissue-resident memory T cells in gastrointestinal tumors and looks to the future of their prospect in immunotherapy to provide a reference for clinical application.

Indexed as

Gastrointestinal NeoplasmsMemory T CellsBiomarkersHumansImmunologic MemoryT-Lymphocyte SubsetsTumor MicroenvironmentBiomarkersanti-tumor responsecancer immunotherapygastrointestinal tumortissue resident memory Ttumor immune microenvironment

Identifiers

PMID36969190
PMCPMC10033836

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.