Evidence map›Paper›PMID 36969038›Full record

ArticleFrontiers in oncology2023

Comparison of first-line treatment with bendamustine plus rituximab versus R-CHOP for patients with follicular lymphoma grade 3A: Results of a retrospective study from the Fondazione Italiana Linfomi.

Gloria Margiotta-Casaluci, Sara Bigliardi, Federica Cocito, Erika Meli, Luigi Petrucci, Maura Nicolosi, Ombretta Annibali, Carola Boccomini, Valentina Bozzoli, Alessia Castellino and 8 more

Open access · goldFull text read
In one paragraph

Article in Frontiers in oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 17 institutions in 1 country.

Gloria Margiotta-CasaluciDivision of Hematology, Department of Translational Medicine, AOU Maggiore della Carità, Novara, Italy.
Sara BigliardiOncology Unit, Azienda Unità Sanitaria Locale Modena, Area Sud Sede di Sassuolo, Sassuolo, Italy.
Federica CocitoDepartment of Hematology, San Gerardo University Hospital, Monza, Italy.
Erika MeliDepartment of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Luigi PetrucciDivisions of Hematology, Department of Translation and Precision Medicine, Policlinico Umberto I, Rome, Italy.
Maura NicolosiHematology Unit, Città della Salute e della Scienza, University and Hospital Torino, Torino, Italy.
Ombretta AnnibaliHematology and Bone Marrow Transplant Unit, University Campus Bio-Medico, Rome, Italy.
Carola BoccominiHematology Unit, Città della Salute e della Scienza, University and Hospital Torino, Torino, Italy.
Valentina BozzoliHematology Unit, Hospital Vito Fazzi, Lecce, Italy.
Alessia CastellinoHematology Unit, Hospital Santa Croce e Carle, Cuneo, Italy.
Federica CattinaOncology Unit, Hospital Crema, Crema, Italy.
Natalia CenfraDepartment of Hematology, Ospedale Santa Maria Goretti, Latina, Italy.
Sabino CiavarellaHematology Unit, Laboratory oh Hematology and Cell Therapy, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy.
Sofya KovalchukDivisions of Hematology, Hospital Careggi, Firenze, Italy.
Francesco RotondoDivisions of Hematology, Hospital Papardo, Messina, Italy.
Angelo FamaHematology Unit, IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Jacopo OlivieriHematology Unit, Hospital Santa Maria della Misericordia, Udine, Italy.
Francesco ZajaDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITAzienda Ospedaliera Ospedale Maggiore · ITAzienda Ospedaliera Ospedali Riuniti Papardo Piemonte · ITAzienda Ospedaliera San Gerardo · ITAzienda Ospedaliero-Universitaria Careggi · ITAzienda Sanitaria Ospedaliera S.Croce e Carle Cuneo · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITAzienda Unita' Sanitaria Locale Di Modena · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITIstituto Tumori Bari · ITOspedale Santa Maria della Misericordia di Udine · ITOspedale Santa Maria Goretti · ITOspedale Vito Fazzi · ITPoliclinico Umberto I · ITUniversità Campus Bio-Medico · ITUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversity of Trieste · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the setting of follicular lymphoma (FL), frontline therapy with rituximab, cyclophosphamide, doxorubicin, and prednisone (R-CHOP) has represented for many years the standard of care for patients with symptomatic advanced disease. More recently, the combination of bendamustine plus rituximab (R-B) has emerged as an alternative therapeutic option. We present a retrospective, multicenter, observational study aimed at comparing outcomes and toxicities observed in 145 patients diagnosed with grade 3A FL treated with a first line therapy in 15 Italian Fondazione Italiana Linfomi centers between the 1st of January 2014 and the 30th of May 2018. Seventy patients were treated with R-B and 75 with R-CHOP. In the R-B group, the median age at the time of diagnosis was 67 years compared with 59 years in the R-CHOP group. Patients in R-B group achieved a similar overall response rate (96%

Indexed as

bendamustineCHOPfollicular lymphomagrade 3Arituximab

Identifiers

PMID36969038
PMCPMC10036382
OpenAlexW4323858826

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read99
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.