Evidence map›Paper›PMID 36968982›Full record

ArticleTetrahedron2022

Medicinal chemical optimization of fluorescent pyrrole-based COX-2 probes.

Sachin B Wagh, Vladimir Maslivetc, James J La Clair, Alexander Kornienko

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sachin B WaghThe Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, 78666, USA.
Vladimir MaslivetcThe Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, 78666, USA.
James J La ClairXenobe Research Institute, P. O. Box 3052, San Diego, CA, 92163-1052, USA.
Alexander KornienkoThe Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, 78666, USA.
Texas State University · USXenobe Research Institute · US

Funding

Acid-Sensitive Glioblastoma Prodrugs Derived from Ophiobolin AR15CA227680 · NCI · TEXAS STATE UNIVERSITY · PI KORNIENKO, ALEXANDER · 2019 to 2019
$462k
Tandem Discovery of Drug Leads and Targets via Paal-Knorr reactionR21GM131717 · NIGMS · TEXAS STATE UNIVERSITY · PI KORNIENKO, ALEXANDER, LA CLAIR, JAMES J · 2019 to 2020
$374k
NCI NIH HHS R15 CA227680NIGMS NIH HHS R21 GM131717
6 · The paper itself

Abstract

Recent studies have demonstrated the ability of human prostaglandin-endoperoxide synthase 2 (COX-2) to guide the formation of fluorescent pyrroles through the Paal-Knorr reaction resulting in the discovery of a central motif. This initial discovery prompted further exploration of this motif for the design of COX-2 inhibitors through the modifications of the substituents on the pyrrole core. This effort led to the discovery of a set of pyrroles whose activity was comparable to Celecoxib, an orally prescribed nonsteroidal anti-inflammatory COX-2 inhibitor. Furthermore, structure-activity relationship (SAR) data, important for the discovery of COX-2 inhibitors, has been obtained.

Indexed as

CelecoxibCOX-2Fluorescent probesPaal-KnorrPyrroles

Identifiers

PMID36968982
PMCPMC10034988
OpenAlexW4293386903

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.