Evidence map›Paper›PMID 36968241›Full record

ReviewRoyal Society open science2023

Data-driven spatio-temporal modelling of glioblastoma.

Andreas Christ Sølvsten Jørgensen, Ciaran Scott Hill, Marc Sturrock, Wenhao Tang, Saketh R Karamched, Dunja Gorup, Mark F Lythgoe, Simona Parrinello, Samuel Marguerat, Vahid Shahrezaei

Full text readReview
In one paragraph

Review in Royal Society open science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Go-or-grow models in biology: a monster on a leash.Journal of mathematical biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andreas Christ Sølvsten JørgensenDepartment of Mathematics, Faculty of Natural Sciences, Imperial College London, London SW7 2AZ, UK.ORCID 0000-0003-2276-5779
Ciaran Scott HillDepartment of Neurosurgery, The National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK.ORCID 0000-0002-4488-4034
Marc SturrockDepartment of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin D02 YN77, Ireland.ORCID 0000-0002-7435-5256
Wenhao TangDepartment of Mathematics, Faculty of Natural Sciences, Imperial College London, London SW7 2AZ, UK.ORCID 0000-0002-4063-0846
Saketh R KaramchedDivision of Medicine, Centre for Advanced Biomedical Imaging, University College London (UCL), London WC1E 6BT, UK.ORCID 0000-0003-4031-5915
Dunja GorupDivision of Medicine, Centre for Advanced Biomedical Imaging, University College London (UCL), London WC1E 6BT, UK.ORCID 0000-0002-3756-7452
Mark F LythgoeDivision of Medicine, Centre for Advanced Biomedical Imaging, University College London (UCL), London WC1E 6BT, UK.ORCID 0000-0002-4945-0171
Simona ParrinelloSamantha Dickson Brain Cancer Unit, UCL Cancer Institute, London WC1E 6DD, UK.ORCID 0000-0003-0820-6292
Samuel MargueratGenomics Translational Technology Platform, UCL Cancer Institute, University College London, London WC1E 6DD, UK.ORCID 0000-0002-2402-3165
Vahid ShahrezaeiDepartment of Mathematics, Faculty of Natural Sciences, Imperial College London, London SW7 2AZ, UK.ORCID 0000-0002-4013-5458

Funding

Cancer Research UK 29787
6 · The paper itself

Abstract

Mathematical oncology provides unique and invaluable insights into tumour growth on both the microscopic and macroscopic levels. This review presents state-of-the-art modelling techniques and focuses on their role in understanding glioblastoma, a malignant form of brain cancer. For each approach, we summarize the scope, drawbacks and assets. We highlight the potential clinical applications of each modelling technique and discuss the connections between the mathematical models and the molecular and imaging data used to inform them. By doing so, we aim to prime cancer researchers with current and emerging computational tools for understanding tumour progression. By providing an in-depth picture of the different modelling techniques, we also aim to assist researchers who seek to build and develop their own models and the associated inference frameworks. Our article thus strikes a unique balance. On the one hand, we provide a comprehensive overview of the available modelling techniques and their applications, including key mathematical expressions. On the other hand, the content is accessible to mathematicians and biomedical scientists alike to accommodate the interdisciplinary nature of cancer research.

Indexed as

agent-based modellingBayesian inferencedata-driven modellingglioblastomareaction–diffusion equations

Identifiers

PMID36968241
PMCPMC10031411

What OpenQuestion holds

Textfull text, public
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.