Evidence map›Paper›PMID 36968084›Full record

ArticleiScience2023

Mathematical modeling and biochemical analysis support partially ordered calmodulin-myosin light chain kinase binding.

Melissa J S MacEwen, Domnita-Valeria Rusnac, Henok Ermias, Timothy M Locke, Hayden E Gizinski, Joseph P Dexter, Yasemin Sancak

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Cerebral capillary computation.American journal of physiology. Cell physiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Melissa J S MacEwenDepartment of Pharmacology, University of Washington, Seattle, WA 98195, USA.
Domnita-Valeria RusnacDepartment of Pharmacology, University of Washington, Seattle, WA 98195, USA.
Henok ErmiasDepartment of Pharmacology, University of Washington, Seattle, WA 98195, USA.
Timothy M LockeDepartment of Pharmacology, University of Washington, Seattle, WA 98195, USA.
Hayden E GizinskiDepartment of Pharmacology, University of Washington, Seattle, WA 98195, USA.
Joseph P DexterData Science Initiative and Department of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Yasemin SancakDepartment of Pharmacology, University of Washington, Seattle, WA 98195, USA.
University of Washington · USEvolutionary Genomics (United States) · US

Funding

Pharmacological Sciences SupplementT32GM007750 · NIGMS · UNIVERSITY OF WASHINGTON · PI ATKINS, WILLIAM M · 1985 to 2023
$12.6M
NIGMS NIH HHS T32 GM007750
6 · The paper itself

Abstract

Activation of myosin light chain kinase (MLCK) by calcium ions (Ca

Indexed as

Biochemical mechanismBiochemistryIn silico biology

Identifiers

PMID36968084
PMCPMC10031086
OpenAlexW4319166190

What OpenQuestion holds

Textfull text, public
LicenceCC BY
reference markers read1
measurements read320
identifiers read2
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.