ArticleFrontiers in aging neuroscience2023
Cortical activation and functional connectivity during locomotion tasks in Parkinson's disease with freezing of gait.
Article in Frontiers in aging neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 12 citations in OpenAlex.
- Cerebral cortical activation and functional connectivity characteristics of children with unilateral cerebral palsy during a single-session virtual reality throwing motor task: a functional near-infrared spectroscopy study.Frontiers in rehabilitation sciences · 2026Article
- Associations of different exercise modalities with balance performance and cortical hemodynamic responses in older adults with mild cognitive impairment.Frontiers in physiology · 2026Article
- The mechanism of external cueing interventions in improving freezing of gait in Parkinson's disease: an fNIRS study.Frontiers in aging neuroscience · 2026Article
- Sensory integration deficits in Parkinson's disease with freezing of gait: cortical network dynamics and paradoxical dopaminergic modulation.Journal of neurology · 2025Article
- Characteristics of brain glucose metabolism in Parkinson's disease patients with freezing of gait: a study based onBMC neurology · 2025Article
- Neural signatures of turn-induced freezing of gait in Parkinson's disease: insights from phase-specific cortico-subthalamic dynamics.NPJ Parkinson's disease · 2025Article
- Effects of robot-assisted hand function therapy on brain functional mechanisms: a synchronized study using fNIRS and sEMG.Frontiers in medicine · 2024Article
- Exploring the application and challenges of fNIRS technology in early detection of Parkinson's disease.Frontiers in aging neuroscience · 2024Article
- Freezing of gait in Parkinson's disease is related to imbalanced stopping-related cortical activity.Brain communications · 2024Article
- Decrease in walking ability with increased functional connectivity between multiple brain areas in Parkinson's disease: a functional near-infrared spectroscopy study.Frontiers in aging neuroscience · 2024Article
- Cortical activation of neuromuscular electrical stimulation synchronized mirror neuron rehabilitation strategies: an fNIRS study.Frontiers in neurology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Freezing of gait (FoG) is a severely disabling symptom in Parkinson's disease (PD). The cortical mechanisms underlying FoG during locomotion tasks have rarely been investigated. Objectives: We aimed to compare the cerebral haemodynamic response during FoG-prone locomotion tasks in patients with PD and FoG (PD-FoG), patients with PD but without FoG (PD-nFoG), and healthy controls (HCs). Methods: Twelve PD-FoG patients, 10 PD-nFoG patients, and 12 HCs were included in the study. Locomotion tasks included normal stepping, normal turning and fast turning ranked as three difficulty levels based on kinematic requirements and probability of provoking FoG. During each task, we used functional near-infrared spectroscopy to capture concentration changes of oxygenated haemoglobin (ΔHBO Results: PD-FoG patients spent a nearly significant longer time completing locomotion tasks than PD-nFoG patients. Compared with PD-nFoG patients, they showed weaker activation (less ΔHBO Conclusion: Insufficient compensatory cortical activation and depletion of functional connectivity during complex locomotion in PD-FoG patients could be potential mechanisms underlying FoG. Clinical trial registration: Chinese clinical trial registry (URL: http://www.chictr.org.cn, registration number: ChiCTR2100042813).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.