Evidence map›Paper›PMID 36967819›Full record

ArticleFrontiers in aging neuroscience2023

Characteristics of fatigue in Parkinson's disease: A longitudinal cohort study.

Xiaoxia Zhou, Yaqin Xiang, Tingwei Song, Yuwen Zhao, Hongxu Pan, Qian Xu, Yase Chen, Qiying Sun, Xinyin Wu, Xinxiang Yan and 5 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
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  5. Behavioral disorders in Parkinson disease: current view.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Xiaoxia ZhouDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Yaqin XiangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Tingwei SongDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Yuwen ZhaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Hongxu PanDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Qian XuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Yase ChenDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Qiying SunDepartment of Geriatrics, Xiangya Hospital, Central South University, Changsha, China.
Xinyin WuDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China.
Xinxiang YanDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Jifeng GuoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Beisha TangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Lifang LeiDepartment of Neurology, The Third Xiangya Hospital, Central South University, Changsha, China.
Zhenhua LiuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
for Parkinson's Disease & Movement Disorders Multicenter Database and Collaborative Network in China (PD-MDCNC)
Xiangya Hospital Central South University · CNCentral South University · CNThird Xiangya Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To assess the prevalence, evolution, clinical characteristics, correlates and predictors of fatigue as well as to investigate the influence of comorbid fatigue on the longitudinal changes in motor and non-motor symptoms over a 2-year longitudinal follow-up period in a large cohort of patients with Parkinson's disease (PD). Materials and methods: A total of 2,100 PD patients were enrolled from the Parkinson's Disease & Movement Disorders Multicenter Database and Collaborative Network in China (PD-MDCNC), and their motor and non-motor symptoms were assessed biennially using comprehensive scales, including the 16-item Parkinson Fatigue Scale (PFS-16). Each PD patient was categorized as PD with or without fatigue on the basis of a cut-off mean PFS-16 score of 3.3. Results: The prevalence of fatigue in our cohort was 36.8%. Compared to PD patients without fatigue, PD patients with fatigue were more likely to be older, have a longer disease duration, and higher baseline levodopa equivalent daily dose (all Conclusion: Increased disease severity, presence of the PIGD subtype, EDS, and wearing-off were associated with fatigue in PD patients. Significant subgroup-level differences were observed in the progression of motor and non-motor symptoms across different fatigue subgroups of PD patients.

Indexed as

fatiguelongitudinalParkinson’s diseasePD-MDCNCprogression

Identifiers

PMID36967819
PMCPMC10036570
OpenAlexW4323857575

What OpenQuestion holds

Textfull text, public
LicenceCC BY
reference markers read1
measurements read98
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.