Evidence map›Paper›PMID 36967724›Full record

ArticleBiomaterials and biosystems2023

Decellularization compromises mechanical and structural properties of the native trachea.

Allison M Greaney, Abhay B Ramachandra, Yifan Yuan, Arina Korneva, Jay D Humphrey, Laura E Niklason

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials and biosystems, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Allison M GreaneyDepartment of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
Abhay B RamachandraDepartment of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
Yifan YuanVascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT 06511, USA.
Arina KornevaDepartment of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
Jay D HumphreyDepartment of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
Laura E NiklasonDepartment of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
Yale University · US

Funding

Reconstructing native soluble cues in vascularized whole lung scaffoldsK99HL159261 · NHLBI · YALE UNIVERSITY · PI YUAN, YIFAN · 2022 to 2023
$245k
The Role of Macrophages in Pulmonary Regeneration using a Bioengineered Whole Lung Tissue ModelF32HL162428 · NHLBI · YALE UNIVERSITY · PI GREANEY, ALLISON MARIE · 2022 to 2024
$213k
NHLBI NIH HHS F32 HL162428NHLBI NIH HHS K99 HL159261
6 · The paper itself

Abstract

Tracheal replacement using tissue engineering technologies offers great potential to improve previously intractable clinical interventions, and interest in this area has increased in recent years. Many engineered airway constructs currently rely on decellularized native tracheas to serve as the scaffold for tissue repair. Yet, mechanical failure leading to airway narrowing and collapse remains a major cause of morbidity and mortality following clinical implantation of decellularized tracheal grafts. To understand better the factors contributing to mechanical failure

Indexed as

Airway replacementBiomechanicsDecellularizationTissue engineeringTrachea mechanics

Identifiers

PMID36967724
PMCPMC10036236
OpenAlexW4318939150

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.