ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2023
Microvascular dysfunction associated with unfavorable venous outflow in acute ischemic stroke patients.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Prognostic value of cerebral venous outflow profiles for outcomes prediction following reperfusion therapy in acute ischemic stroke: a meta-analysis.Neuroradiology · 2025Pooled it
- Cortical venous opacification score predicts outcomes after thrombectomy in large vessel occlusion stroke: a systematic review and meta-analysis.Neuroradiology · 2025Pooled it
- Mediation of ghost infarct core on prognosis by venous outflow and net water uptake after stroke thrombectomy.European radiology · 2026Article
- Association of cerebral collateral cascade with early neurological deterioration after endovascular thrombectomy in patients with acute ischemic stroke.Quantitative imaging in medicine and surgery · 2026Article
- Combined assessment of FLAIR vascular hyperintensities and cortical venous outflow for outcome prediction in acute middle cerebral artery occlusion.Frontiers in human neuroscience · 2026Article
- Collateral status correlates with stroke outcomes mediated by early infarct growth rate in patients with acute large vessel occlusion.Quantitative imaging in medicine and surgery · 2025Article
- Paramagnetic rim lesions are associated with choroid plexus inflammation and expansion over 5 years in people with multiple sclerosis.Journal of neurology · 2025Article
- Dynamic CTA-Based Whole-Brain Arterial-Venous Collateral Assessment for Predicting Futile Recanalization in Acute Ischemic Stroke.Aging and disease · 2025Article
- Venous outflow time profiles: promising imaging biomarkers for futile recanalization in acute ischemic stroke due to large vessel occlusion.Frontiers in neurology · 2025Article
- Exploring ischemic core growth rate and endovascular therapy benefit in large core patients.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Prolonged Venous Transit Is Associated With Lower Likelihood of Favorable Clinical Recovery in Reperfused Anterior Circulation Large-Vessel Occlusion Stroke.Stroke (Hoboken, N.J.) · 2024Article
- The benefit of favorable venous outflow profile is mediated through reduced microvascular dysfunction in acute ischemic stroke.European stroke journal · 2024Article
- Recent advances in mechanistic, therapeutic, and diagnostic research of cerebrovascular diseases: updates from brain & BrainPET 2022.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Advances in Collateral Neuroimaging for Acute Ischemic Stroke: Redefining Time and Tissue Windows in the Reperfusion Era.Journal of neuroimaging : official journal of the American Society of NeuroimagingReview
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unfavorable venous outflow (VO) is associated with cerebral edema, which represents microvascular dysfunction. This study estimated the relationship between VO and microvascular function in acute ischemic stroke patients. We retrospectively included 102 MCA/ICA occluded patients with anterior circulation infarction who underwent reperfusion therapy between July 2017 and April 2022. Unfavorable VO was defined as a cortical vein opacification score of 0-3 and favorable VO as that of 4-6. The clinical characteristics, collateral status, microvascular integrity, and outcomes were compared between patients with favorable and unfavorable VO. Multivariate analysis and receiver operator characteristic (ROC) analysis were used. The patients with unfavorable VO had higher extravascular-extracellular volume fraction (Ve) in the infarct core and a lower percentage of robust arterial collateral circulation. ROC analysis revealed that Ve in the infarct core predicts unfavorable VO (AUC = 0.67, sensitivity = 65.08%, specificity = 69.23%). The higher Ve in the infarct core (odds ratio = 1.011, 95% CI = 1.000-1.021,
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.