Evidence map›Paper›PMID 36967673›Full record

ArticleImmunology and cell biology2023

Hypercapnia alters mitochondrial gene expression and acylcarnitine production in monocytes.

David E Phelan, Catarina Mota, Moritz J Strowitzki, Masahiko Shigemura, Jacob I Sznajder, Louise Crowe, Joanne C Masterson, Sophie E Hayes, Ben Reddan, Xiaofei Yin and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Immunology and cell biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Activity-based CORedox biology · 2026
    Article
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  4. Article
  5. Review
  6. Bioenergetics and metabolism of the pulmonary endothelium. Scientific session I: ReSPIRE 2025.American journal of physiology. Lung cellular and molecular physiology · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

David E PhelanSchool of Medicine, University College Dublin, Dublin, Ireland.
Catarina MotaSchool of Medicine, University College Dublin, Dublin, Ireland.
Moritz J StrowitzkiSchool of Medicine, University College Dublin, Dublin, Ireland.
Masahiko ShigemuraDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Jacob I SznajderDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Louise CroweAllergy, Inflammation & Remodeling Research Laboratory, Kathleen Lonsdale Institute for Human Health Research, Department of Biology, Maynooth University, Maynooth, County Kildare, Ireland.
Joanne C MastersonAllergy, Inflammation & Remodeling Research Laboratory, Kathleen Lonsdale Institute for Human Health Research, Department of Biology, Maynooth University, Maynooth, County Kildare, Ireland.
Sophie E HayesSchool of Medicine, University College Dublin, Dublin, Ireland.
Ben ReddanSchool of Medicine, University College Dublin, Dublin, Ireland.
Xiaofei YinConway Institute of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland.
Lorraine BrennanConway Institute of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland.
Daniel CreanConway Institute of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland.
Eoin P CumminsSchool of Medicine, University College Dublin, Dublin, Ireland.ORCID 0000-0002-9346-8299
University College Dublin · IENational University of Ireland, Maynooth · IENorthwestern University · US

Funding

Role of hypercapnia on the lung airwaysR01HL147070 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2019 to 2022
$1.9M
NHLBI NIH HHS R01 HL147070Science Foundation Ireland 15/RI/3215Science Foundation Ireland 18/RI/5702Science Foundation Ireland SFI/15/CDA/3490Science Foundation Ireland SFI/FRL/4863
6 · The paper itself

Abstract

CO

Indexed as

HypercapniaPulmonary Disease, Chronic ObstructiveAnimalsCarbon DioxideCarnitineFatty AcidsGene ExpressionGenes, MitochondrialHumansLipopolysaccharidesMiceMonocytesacylcarnitineCarbon DioxideCarnitineFatty AcidsLipopolysaccharidesAcylcarnitinecarbon dioxideCO2gene expressionhypercapniamitochondriamonocyteRNA-seq

Identifiers

PMID36967673
PMCPMC10330468
OpenAlexW4361010165

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.