Evidence map›Paper›PMID 36967457›Full record

ArticlePhysiological reports2023

Characteristics of acid-sensing ion channel currents in male rat muscle dorsal root ganglion neurons following ischemia/reperfusion.

Qin Li, Lu Qin, Jianhua Li

Open access · goldFull text read
In one paragraph

Article in Physiological reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Qin LiHeart and Vascular Institute, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Lu QinHeart and Vascular Institute, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0001-7305-0568
Jianhua LiHeart and Vascular Institute, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0002-0513-3983
Pennsylvania State University · US

Funding

Project 3: Role Played by ASIC, P2X and EP4 Receptors in the Exercise Pressor Reflex in Health and Simulated PADP01HL134609 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KAUFMAN, MARC PETER · 2017 to 2021
$9.4M
Exercise Pressor Reflex in Peripheral Artery Disease: Roles of Flow Limitation and ReperfusionR01HL164571 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI JIAN CUI, JIANHUA LI · 2022 to 2026
$3.9M
Exercise pressor reflex in peripheral artery disease: beneficial effects of heating and mechanismsR01HL141198 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI CUI, JIAN, LI, JIANHUA · 2019 to 2023
$3.7M
American Heart Association-American Stroke Association grant# 940567NHLBI NIH HHS P01 HL134609NHLBI NIH HHS R01 HL141198NHLBI NIH HHS R01 HL164571NIH HHS NIH R01 HL141198NIH HHS R01 HL164571
6 · The paper itself

Abstract

Peripheral artery diseases (PAD) increases muscle afferent nerve-activated reflex sympathetic nervous and blood pressure responses during exercise (termed as exercise pressor reflex). However, the precise signaling pathways leading to the exaggerated autonomic responses in PAD are undetermined. Considering that limb ischemia/reperfusion (I/R) is a feature of PAD, we determined the characteristics of acid-sensing ion channel (ASIC) currents in muscle dorsal root ganglion (DRG) neurons under the conditions of hindlimb I/R and ischemia of PAD. In particular, we examined ASIC currents in two distinct subpopulations, isolectin B

Indexed as

Acid Sensing Ion ChannelsGanglia, SpinalAnimalsIschemiaMaleMuscle, SkeletalNeurons, AfferentRatsRats, Sprague-DawleySensory Receptor CellsAcid Sensing Ion Channelsacid-sensing ion channelsdorsal root ganglionischemia-reperfusionperipheral artery disease

Identifiers

PMID36967457
PMCPMC10040404
OpenAlexW4360976070

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read63
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.